Journal article
The Novel ASIC2 Locus is Associated with Severe Gingival Inflammation
JDR clinical and translational research, Vol.1(2), pp.163-170
07/2016
DOI: 10.1177/2380084416645290
PMCID: PMC5409514
PMID: 28459102
Abstract
An increasing body of evidence suggests a significant genetic regulation of inflammatory response mechanisms; however, little is known regarding the genetic determinants of severe gingival inflammation (GI). We conducted a genome-wide association study of severe GI among 4077 European American adults, participants in the Dental Atherosclerosis Risk In Communities cohort. The severe GI trait was defined dichotomously using the 90
percentile of gingival index ≥2 extent score. Genotyping was performed with the Affymetrix 6.0 array platform and an imputed set of 2.5 million markers, based on HapMap Phase II CEU build 36, was interrogated. Genetic models were based on logistic regression and controlled for ancestry (10 principal components), sex, age, and examination center. One locus on chromosome 17 met genome-wide statistical significance criteria-lead single nucleotide polymorphism (SNP): rs11652874 [minor allele frequency=0.06, intronic to
(acid sensing ionic channel-2, formerly named
); odds ratio=2.1, 95% confidence interval=1.6-2.7, p=3.9×10
]. This association persisted among subjects with severe periodontitis and was robust to adjustment for microbial plaque index. Moreover, the minor [G] allele was associated with higher levels of severe GI in stratified analyses among subsets of participants with high load of either "red" or "orange" complex pathogens, although this association was not statistically significant. While these results will require replication in independent samples and confirmation by mechanistic studies, this locus appears as a promising candidate for severe gingival inflammation. Our findings suggest that genetic variation in
is significantly associated with severe gingival inflammation and the association is plaque-independent.
Details
- Title: Subtitle
- The Novel ASIC2 Locus is Associated with Severe Gingival Inflammation
- Creators
- Shaoping Zhang - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel HillKimon Divaris - Department of Epidemiology, UNC Gillings School of Global Public Health, University of North Carolina at Chapel HillKevin Moss - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel HillNing Yu - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel HillSilvana Barros - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel HillJulie Marchesan - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel HillThiago Morelli - Department of Periodontology, School of Dentistry, University of North Carolina at Chapel HillCary Agler - Center for Oral & Craniofacial Health Sciences, School of Dentistry, University of North Carolina at Chapel HillSteven J Kim - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel HillDi Wu - Department of Periodontology, School of Dentistry, University of North Carolina at Chapel HillKari E North - Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill Gillings School of Global Public HealthJames Beck - Department of Dental Ecology, School of Dentistry, University of North Carolina at Chapel HillSteven Offenbacher - Center for Oral and Systemic Disease, School of Dentistry, University of North Carolina at Chapel Hill
- Resource Type
- Journal article
- Publication Details
- JDR clinical and translational research, Vol.1(2), pp.163-170
- Publisher
- United States
- DOI
- 10.1177/2380084416645290
- PMID
- 28459102
- PMCID
- PMC5409514
- ISSN
- 2380-0844
- eISSN
- 2380-0852
- Grant note
- HHSN268201100010C / NHLBI NIH HHS UL1 RR025005 / NCRR NIH HHS HHSN268201100005C / NHLBI NIH HHS R01 HL059367 / NHLBI NIH HHS HHSN268201100007C / NHLBI NIH HHS U01 HG004402 / NHGRI NIH HHS T90 DE021986 / NIDCR NIH HHS HHSN268201100008C / NHLBI NIH HHS HHSN268201100008I / NHLBI NIH HHS R01 HL086694 / NHLBI NIH HHS R90 DE022527 / NIDCR NIH HHS HHSN268201100005G / NHLBI NIH HHS R01 DE023836 / NIDCR NIH HHS HHSN268201100005I / NHLBI NIH HHS P30 ES010126 / NIEHS NIH HHS R01 HL087641 / NHLBI NIH HHS HHSN268201100006C / NHLBI NIH HHS HHSN268201100009C / NHLBI NIH HHS R01 DE011551 / NIDCR NIH HHS HHSN268201100011C / NHLBI NIH HHS R01 DE021418 / NIDCR NIH HHS HHSN268201100011I / NHLBI NIH HHS HHSN268201100007I / NHLBI NIH HHS HHSN268201100009I / NHLBI NIH HHS
- Language
- English
- Date published
- 07/2016
- Academic Unit
- Periodontics
- Record Identifier
- 9984066096202771
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