Journal article
The Parkinson Progression Marker Initiative (PPMI)
Progress in neurobiology, Vol.95(4), pp.629-635
12/2011
DOI: 10.1016/j.pneurobio.2011.09.005
PMID: 21930184
Abstract
The Parkinson Progression Marker Initiative (PPMI) is a comprehensive observational, international, multi-center study designed to identify PD progression biomarkers both to improve understanding of disease etiology and course and to provide crucial tools to enhance the likelihood of success of PD modifying therapeutic trials. The PPMI cohort will comprise 400 recently diagnosed PD and 200 healthy subjects followed longitudinally for clinical, imaging and biospecimen biomarker assessment using standardized data acquisition protocols at twenty-one clinical sites. All study data will be integrated in the PPMI study database and will be rapidly and publically available through the PPMI web site- www.ppmi-info.org. Biological samples including longitudinal collection of blood, cerebrospinal fluid (CSF) and urine will be available to scientists by application to an independent PPMI biospecimen review committee also through the PPMI web site. PPMI will rely on a partnership of government, PD foundations, industry and academics working cooperatively. This approach is crucial to enhance the potential for success of this ambitious strategy to develop PD progression biomarkers that will accelerate research in disease modifying therapeutics.
Details
- Title: Subtitle
- The Parkinson Progression Marker Initiative (PPMI)
- Creators
- Kenneth MarekDanna JenningsShirley LaschAndrew SiderowfCaroline TannerNorbert SchuffTanya SimuniYing Zhang - University of IowaArthur TogaKaren CrawfordAlison AnsbachPasquale De BlasioMichele PiovellaJohn TrojanowskiLes ShawAndrew SingletonKeith HawkinsJamie EberlingDeborah BrooksDavid RussellLaura LearyStewart FactorBarbara SommerfeldPenelope HogarthEmily PighettiKaren WilliamsDavid StandaertWerner PoeweSam FrankStephanie GuthrieRobert HauserBrit MollenhauerHolly DelgadoCathi-Ann Thomas - Boston UniversityJoseph JankovicParacelsus-Elena KlinikChristine HunterIrene RichardChris CoffeyMatthew SternTodd ShererBaochan TranCheryl DeeleyKarl KieburtzJim LeverenzMark FrasierEmily FlaggSohini ChowdhuryMarne BacaLinda ReesClaire MeunierFabienne SprengerAlice RudolphElisabeth LangCindy CasaceliHolly ShillJohn SeibylSanja ObradovSusan MendickHubert FernandezAdrienna WintersDaniela BergKatharina GaussDouglas GalaskoDeborah FontaineZoltan MariMelissa GerstenhaberDavid BrooksSophie MalloyPaolo BaroneKatia LongoTom ComeryBernard RavinaIgor GrachevKim GallagherMichelle CollinsKatherine L WidnellSuzanne OstrowizkiPaulo FontouraTony HoJohan LuthmanMarcel van der BrugAlastair D ReithPeggy TaylorExecutive Steering Comm
- Resource Type
- Journal article
- Publication Details
- Progress in neurobiology, Vol.95(4), pp.629-635
- DOI
- 10.1016/j.pneurobio.2011.09.005
- PMID
- 21930184
- NLM abbreviation
- Prog Neurobiol
- ISSN
- 0301-0082
- eISSN
- 1873-5118
- Language
- English
- Date published
- 12/2011
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997345102771
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