Journal article
The Phenotype of Circulating Neutrophils during Visceral Leishmaniasis
The American journal of tropical medicine and hygiene, Vol.97(3), pp.767-770
09/2017
DOI: 10.4269/ajtmh.16-0722
PMCID: PMC5590568
PMID: 28820688
Abstract
Visceral leishmaniasis (VL) is a chronic parasitic disease associated with suppressed T cell responses. Although parasites reside intracellularly in macrophages during chronic VL, neutrophils are the first host cell to infiltrate the infection site and phagocytose the parasite. Subsets of neutrophils with unusual characteristics have been documented in human VL, but whether the total neutrophil population is aberrant during disease is not known. Therefore, we examined phenotypic characteristics of unfractionated polymorphonuclear leukocyte (neutrophils) from subjects with active VL, and compared these with neutrophils from healthy controls or subjects who have been treated for VL. The data showed decreased mRNA and diminished amounts of the neutrophil chemoattractant CXCL8 (interleukin [IL]-8), increased IL-10 mRNA and protein, and elevated transcripts encoding arginase-1, which is involved in suppressing T cell responses. Neutrophils from VL subjects showed enhanced capacity to phagocytose
spp. promastigotes. The results suggest that neutrophils may contribute to immunosuppression in subjects with active VL.
Details
- Title: Subtitle
- The Phenotype of Circulating Neutrophils during Visceral Leishmaniasis
- Creators
- Smriti Sharma - Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, IndiaShweta Srivastva - Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, IndiaRichard E Davis - Interdisciplinary Program in Immunology, University of Iowa, Iowa City, IowaSiddharth Sankar Singh - Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, IndiaRajiv Kumar - Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, IndiaSusanne Nylén - Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, SwedenMary E Wilson - Departments of Internal Medicine and Microbiology, University of Iowa, Iowa City, IowaShyam Sundar - Department of Medicine, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
- Resource Type
- Journal article
- Publication Details
- The American journal of tropical medicine and hygiene, Vol.97(3), pp.767-770
- Publisher
- United States
- DOI
- 10.4269/ajtmh.16-0722
- PMID
- 28820688
- PMCID
- PMC5590568
- ISSN
- 1476-1645
- eISSN
- 1476-1645
- Language
- English
- Date published
- 09/2017
- Academic Unit
- Microbiology and Immunology; International Programs; Epidemiology; Internal Medicine
- Record Identifier
- 9984002397102771
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