Journal article
The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell
Nature communications, Vol.15(1), 526
01/16/2024
DOI: 10.1038/s41467-023-44230-x
PMCID: PMC10791687
PMID: 38228630
Abstract
The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.
Details
- Title: Subtitle
- The Piezo channel is a mechano-sensitive complex component in the mammalian inner ear hair cell
- Creators
- Jeong Han Lee - University of Nevada, RenoMaria C Perez-Flores - University of Nevada, RenoSeojin Park - University of Nevada, RenoHyo Jeong Kim - University of Nevada, RenoYingying Chen - University of Nevada, RenoMincheol Kang - Wrexham UniversityJennifer Kersigo - University of IowaJinsil Choi - University of Nevada, RenoPhung N Thai - University of California, DavisRyan L Woltz - University of California, DavisDolores Columba Perez-Flores - University of Nevada, RenoGuy Perkins - University of California San DiegoChoong-Ryoul Sihn - University of Nevada, RenoPauline Trinh - University of California, DavisXiao-Dong Zhang - University of California, DavisPadmini Sirish - University of California, DavisYao Dong - University of California, DavisWayne Wei Feng - University of California, DavisIsaac N Pessah - University of California, DavisRose E Dixon - University of California, DavisBernd Sokolowski - University of South FloridaBernd Fritzsch - University of IowaNipavan Chiamvimonvat - VA Northern California Health Care SystemEbenezer N Yamoah - University of Nevada, Reno
- Resource Type
- Journal article
- Publication Details
- Nature communications, Vol.15(1), 526
- DOI
- 10.1038/s41467-023-44230-x
- PMID
- 38228630
- PMCID
- PMC10791687
- NLM abbreviation
- Nat Commun
- ISSN
- 2041-1723
- eISSN
- 2041-1723
- Grant note
- R01 HL159304 / NHLBI NIH HHS R01 AG063796 / NIA NIH HHS P01 AG051443 / NIA NIH HHS R01 HL085844 / NHLBI NIH HHS R01 DC016099 / NIDCD NIH HHS R56 HL167932 / NHLBI NIH HHS F31 HL170698 / NHLBI NIH HHS I01 CX001490 / CSRD VA R56 HL138392 / NHLBI NIH HHS I01 BX000576 / BLRD VA S10 RR022498 / NCRR NIH HHS P20 GM130459 / NIGMS NIH HHS F32 HL151130 / NHLBI NIH HHS R01 HL137228 / NHLBI NIH HHS R01 AG060504 / NIA NIH HHS R01 HL085727 / NHLBI NIH HHS R01 DC015135 / NIDCD NIH HHS R01 DC015252 / NIDCD NIH HHS R01 HL158961 / NHLBI NIH HHS
- Language
- English
- Date published
- 01/16/2024
- Academic Unit
- Iowa Neuroscience Institute; Biology; Craniofacial Anomalies Research Center
- Record Identifier
- 9984548406002771
Metrics
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