Journal article
The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors
Cancers, Vol.12(6), p.1355
05/26/2020
DOI: 10.3390/cancers12061355
PMCID: PMC7352167
PMID: 32466456
Abstract
The Mediterranean diet (MD) has been reported to have beneficial effects on breast cancer and cardiovascular diseases. Recently, microRNAs (miRNAs) have been suggested as biomarkers for the diagnosis and disease prognosis in cancer and cardiovascular diseases. We evaluated the influence of the MD on the plasma-derived extracellular vesicle miRNA signature of overweight breast cancer survivors. Sixteen participants instructed to adhere to the MD for eight weeks were included in this study. To curate differentially expressed miRNAs after MD intervention, we employed two methods: significance analysis of microarrays and DESeq2. The selected miRNAs were analyzed using ingenuity pathway analysis. After an eight-week intervention, body mass index, waist circumference, fasting glucose, fasting insulin, and homeostatic model assessment for insulin resistance were significantly improved. Expression levels of 798 miRNAs were comprehensively analyzed, and 42 extracellular vesicle miRNAs were significantly differentially regulated after the eight-week MD (36 were up and 6 were down-regulated). We also identified enriched pathways in genes regulated by differentially expressed 42 miRNAs, which include signaling associated with breast cancer, energy metabolism, glucose metabolism, and insulin. Our study indicates that extracellular vesicle miRNAs differentially expressed as a result of the MD might be involved in the mechanisms that relate to cardiometabolic risk factors in overweight breast cancer survivors.
Details
- Title: Subtitle
- The Possible Influence of Mediterranean Diet on Extracellular Vesicle miRNA Expression in Breast Cancer Survivors
- Creators
- Yu-Jin Kwon - Severance HospitalYoung-Eun Cho - National Institute of Nursing ResearchA-Ra Cho - Yonsei UniversityWon Jun Choi - Yonsei UniversitySijung YunHyunki Park - Yonsei UniversityHyung-Suk Kim - NINR, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USAAnn K. Cashion - National Institute of Nursing ResearchJessica Gill - National Institute of Nursing ResearchHyangkyu Lee - Yonsei UniversityJi-Won Lee - Gangnam Severance Hospital
- Resource Type
- Journal article
- Publication Details
- Cancers, Vol.12(6), p.1355
- DOI
- 10.3390/cancers12061355
- PMID
- 32466456
- PMCID
- PMC7352167
- NLM abbreviation
- Cancers (Basel)
- ISSN
- 2072-6694
- eISSN
- 2072-6694
- Publisher
- Mdpi
- Number of pages
- 17
- Grant note
- NRF-2018R1D1A1B07049223 / Bio and Medical Technology Development Program through the National Research Foundation of Korea - Ministry of Science, ICT, and Future Planning; National Research Foundation of Korea NRF-2019R1A2C1010043 / National Research Foundation of Korea (NRF) - Korea government (MEST); Ministry of Education, Science & Technology (MEST), Republic of Korea; National Research Foundation of Korea; Korean Government 20002781 / Technology Innovation Program - Ministry of Trade, Industry & Energy (MOTIE, Korea); Ministry of Trade, Industry & Energy (MOTIE), Republic of Korea National Institute of Nursing Research in National Institutes of Health
- Language
- English
- Date published
- 05/26/2020
- Academic Unit
- Nursing; Fraternal Order of Eagles Diabetes Research Center
- Record Identifier
- 9984370644502771
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