Journal article
The Potential Role of Fatty Acids in Treating Diabetic Neuropathy
Current diabetes reports, Vol.18(10), pp.86-10
10/01/2018
DOI: 10.1007/s11892-018-1046-9
PMCID: PMC6816026
PMID: 30145729
Abstract
Purpose of review This review will summarize recent findings of the effect of supplemental fatty acids, with an emphasis on omega-3 polyunsaturated fatty acids, as a treatment for diabetic peripheral neuropathy.
Recent findings Pre-clinical studies have provided evidence that treating diabetic rodents with delta linolenic acid (omega-6 18:3) and to a greater extent with eicosapentaenoic and docosahexaenoic acids (omega-3 20:5 and 22:6, respectively) improve and even reverse vascular and neural deficits. Additional studies have shown resolvins, metabolites of eicosapentaenoic and docosahexaenoic acids, can induce neurite outgrowth in neuron cultures and that treating type 1 or type 2 diabetic mice with resolvin D1 or E1 provides benefit for peripheral neuropathy similar to fish oil.
Summary Omega-3 polyunsaturated fatty acids derived from fish oil and their derivatives have anti-inflammatory properties and could provide benefit for diabetic peripheral neuropathy. However, clinical trials are needed to determine whether this statement is true.
Details
- Title: Subtitle
- The Potential Role of Fatty Acids in Treating Diabetic Neuropathy
- Creators
- Mark A. Yorek - Iowa City VA Health Care System
- Resource Type
- Journal article
- Publication Details
- Current diabetes reports, Vol.18(10), pp.86-10
- DOI
- 10.1007/s11892-018-1046-9
- PMID
- 30145729
- PMCID
- PMC6816026
- NLM abbreviation
- Curr Diab Rep
- ISSN
- 1534-4827
- eISSN
- 1539-0829
- Publisher
- Current Medicine Group
- Number of pages
- 10
- Grant note
- RX000889-06 / Department of Veterans Affairs, Veterans Health Administration, Office of Research and Development, Rehabilitation Research and Development; US Department of Veterans Affairs DK107339-03 / National Institute of Diabetes and Digestive and Kidney Diseases from NIH R01DK107399 / NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) I01RX000889 / Veterans Affairs; US Department of Veterans Affairs
- Language
- English
- Date published
- 10/01/2018
- Academic Unit
- Fraternal Order of Eagles Diabetes Research Center; Endocrinology and Metabolism; Internal Medicine
- Record Identifier
- 9984359829302771
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