Journal article
The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions
Journal of allergy and clinical immunology, Vol.149(2), p.488
02/01/2022
DOI: 10.1016/j.jaci.2021.10.035
PMCID: PMC8821377
PMID: 34848210
Abstract
Asthma is a heterogeneous disease, with multiple underlying inflammatory pathways and structural airway abnormalities that impact disease persistence and severity. Recent progress has been made in developing targeted asthma therapeutics, especially for subjects with eosinophilic asthma. However, there is an unmet need for new approaches to treat patients with severe and exacerbation-prone asthma, who contribute disproportionately to disease burden. Extensive deep phenotyping has revealed the heterogeneous nature of severe asthma and identified distinct disease subtypes. A current challenge in the field is to translate new and emerging knowledge about different pathobiologic mechanisms in asthma into patient-specific therapies, with the ultimate goal of modifying the natural history of disease. Here, we describe the effort of asthma researchers and biostatisticians from around the United States. The PrecISE Network was designed to conduct phase II/proof-of-concept clinical trials of precision interventions in the population with severe asthma, and is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health. Using an innovative adaptive platform trial design, the PrecISE Network will evaluate up to 6 interventions simultaneously in biomarker-defined subgroups of subjects. We review the development and organizational structure of the PrecISE Network, and choice of interventions being studied. We hope that the PrecISE Network will enhance our understanding of asthma subtypes and accelerate the development of therapeutics for severe asthma.
Details
- Title: Subtitle
- The Precision Interventions for Severe and/or Exacerbation-Prone (PrecISE) Asthma Network: An overview of Network organization, procedures, and interventions
- Creators
- Steve N. Georas - University of Rochester Medical CenterRosalind J. Wright - Icahn School of Medicine at Mount SinaiAnastasia Ivanova - University of North Carolina at Chapel HillElliot Israel - Brigham and Women's HospitalLisa M. LaVange - University of North Carolina at Chapel HillPraveen Akuthota - University of California San DiegoTara F. Carr - University of ArizonaLoren C. Denlinger - University of Wisconsin–MadisonMerritt L. Fajt - University of PittsburghRajesh Kumar - Lurie Children's HospitalWanda K. O'Neal - University of North Carolina at Chapel HillWanda Phipatanakul - Boston Children's HospitalStanley J. Szefler - University of Colorado DenverMark A. Aronica - Cleveland ClinicLeonard B. Bacharier - Vanderbilt UniversityAllison J. Burbank - University of North Carolina at Chapel HillMario Castro - University of KansasLaura Crotty Alexander - Univ Calif San Diego, Dept Med, Pulm Div, La Jolla, CA 92093 USAJulie Bamdad - National Institutes of HealthJuan Carlos Cardet - University of South FloridaSuzy A. A. Comhair - Cleveland ClinicRonina A. Covar - Natl Jewish Hlth, Denver, CO USAEmily A. DiMango - Columbia University Irving Medical CenterKim Erwin - University of Illinois ChicagoSerpil C. Erzurum - Cleveland ClinicJohn Fahy - University of California, San FranciscoJonathan M. Gaffin - Boston Children's HospitalBenjamin Gaston - Indiana University – Purdue University IndianapolisLynn B. Gerald - University of ArizonaEric A. Hoffman - University of IowaFernando Holguin - University of Colorado DenverDaniel J. Jackson - University of Wisconsin–MadisonJohn James - University of North Carolina at Chapel HillNizar N. Jarjour - University of Wisconsin–MadisonNicholas J. Kenyon - University of California, DavisSumita Khatri - Cleveland ClinicJohn P. Kirwan - Louisiana State UniversityMonica Kraft - University of ArizonaJerry A. Krishnan - University of Illinois ChicagoAndrew H. Liu - University of Colorado DenverMark C. Liu - Johns Hopkins UniversityM. Alison Marquis - University of North Carolina at Chapel HillFernando Martinez - University of ArizonaJacob Mey - Louisiana State UniversityWendy C. Moore - Wake Forest UniversityJames N. Moy - Rush University Medical CenterVictor E. Ortega - Wake Forest UniversityDavid B. Peden - University of North Carolina at Chapel HillEmily Pennington - Cleveland ClinicMichael C. Peters - University of California, San FranciscoKristie Ross - Cleveland ClinicMaria Sanchez - University of North Carolina at Chapel HillLewis J. Smith - Northwestern UniversityRonald L. Sorkness - University of Wisconsin–MadisonMichael E. Wechsler - University of Colorado DenverSally E. Wenzel - University of PittsburghSteven R. White - University of ChicagoJoe Zein - Cleveland ClinicAmir A. Zeki - University of California, DavisPatricia Noel - National Institutes of HealthPrecISE Study Team
- Contributors
- Sean B Fain (Contributor) - University of Iowa, Radiology
- Resource Type
- Journal article
- Publication Details
- Journal of allergy and clinical immunology, Vol.149(2), p.488
- DOI
- 10.1016/j.jaci.2021.10.035
- PMID
- 34848210
- PMCID
- PMC8821377
- NLM abbreviation
- J Allergy Clin Immunol
- ISSN
- 0091-6749
- eISSN
- 1097-6825
- Publisher
- Elsevier
- Number of pages
- 38
- Grant note
- Walter and Carmina Parkes Family Endowed Professorship Gloria M. and Anthony C. Simboli Distinguished Chair in Asthma Research 5U24TR001608 / Duke/Vanderbilt Trial Innovation Center UL1TR002451; UL1TR000427; UL1TR002366; UL1TR002389; UL1TR002489; UL1TR001857; UL1TR001442; UL1TR001872 / National Institutes of Health Clinical & Translational Science Award; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA U24 HL138998; 1UG1HL139054; 1UG1HL139098; 1UG1HL139106; 1UG1HL139117; 1UG1HL139118; 1UG1HL139119; 1UG1HL139123; 1UG1HL139124; 1UG1HL139125; 1UG1HL139126 / National Heart, Lung, and Blood Institute, National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 02/01/2022
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Internal Medicine
- Record Identifier
- 9984274952502771
Metrics
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