Journal article
The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium
Paediatric and perinatal epidemiology, Vol.33(6), pp.490-502
11/2019
DOI: 10.1111/ppe.12592
PMCID: PMC6901022
PMID: 31659792
Abstract
Preconception health may have intergenerational influences. We have formed the PrePARED (Preconception Period Analysis of Risks and Exposures influencing health and Development) research consortium to address methodological, conceptual, and generalisability gaps in the literature.
The consortium will investigate the effects of preconception exposures on four sets of outcomes: (1) fertility and miscarriage; (2) pregnancy-related conditions; (3) perinatal and child health; and (4) adult health outcomes.
A study is eligible if it has data measured for at least one preconception time point, has a minimum of selected core data, and is open to collaboration and data harmonisation.
The included studies are a mix of studies following women or couples intending to conceive, general-health cohorts that cover the reproductive years, and pregnancy/child cohort studies that have been linked with preconception data. The majority of the participating studies are prospective cohorts, but a few are clinical trials or record linkages.
Data analysis will begin with harmonisation of data collected across cohorts. Initial areas of interest include nutrition and obesity; tobacco, marijuana, and other substance use; and cardiovascular risk factors.
Twenty-three cohorts with data on almost 200 000 women have combined to form this consortium, begun in 2018. Twelve studies are of women or couples actively planning pregnancy, and six are general-population cohorts that cover the reproductive years; the remainder have some other design. The primary focus for four was cardiovascular health, eight was fertility, one was environmental exposures, three was child health, and the remainder general women's health. Among other cohorts assessed for inclusion, the most common reason for ineligibility was lack of prospectively collected preconception data.
The consortium will serve as a resource for research in many subject areas related to preconception health, with implications for science, practice, and policy.
Details
- Title: Subtitle
- The Preconception Period analysis of Risks and Exposures Influencing health and Development (PrePARED) consortium
- Creators
- Emily W Harville - Tulane UniversityGita D Mishra - University of QueenslandEdwina Yeung - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentSunni L Mumford - Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USAEnrique F Schisterman - Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentAnne Marie Jukic - National Institute of Environmental Health SciencesElizabeth E Hatch - Boston UniversityEllen M Mikkelsen - Aarhus University HospitalHong Jiang - Fudan UniversityDeborah B Ehrenthal - University of Wisconsin–MadisonChristina A Porucznik - University of UtahJoseph B Stanford - University of UtahShi-Wu Wen - Ottawa Hospital Research InstituteAlysha Harvey - The Ottawa Hospital, Ottawa, ON, CanadaDanielle Symons Downs - Department of Obstetrics and Gynecology, College of Medicine, The Pennsylvania State University, University Park, PA, USAChittaranjan Yajnik - King Edward Memorial Hospital Research CentreDonna Santillan - University of IowaMark Santillan - University of IowaThomas F McElrath - Brigham and Women's HospitalJessica G Woo - Cincinnati Children's Hospital Medical CenterElaine M Urbina - Cincinnati Children's Hospital Medical CenterJorge E Chavarro - Harvard UniversityDaniela Sotres-Alvarez - University of North Carolina at Chapel HillLydia Bazzano - Tulane UniversityJun Zhang - Ministry of Education and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.Anne Steiner - Duke University HospitalErica P Gunderson - Kaiser PermanenteLauren A Wise - Boston University
- Resource Type
- Journal article
- Publication Details
- Paediatric and perinatal epidemiology, Vol.33(6), pp.490-502
- DOI
- 10.1111/ppe.12592
- PMID
- 31659792
- PMCID
- PMC6901022
- NLM abbreviation
- Paediatr Perinat Epidemiol
- ISSN
- 0269-5022
- eISSN
- 1365-3016
- Grant note
- U54 GM104940 / NIGMS NIH HHS UL1 TR001863 / NCATS NIH HHS K23 HD001479 / NICHD NIH HHS R01 ES020488 / NIEHS NIH HHS
- Language
- English
- Date published
- 11/2019
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9984318327802771
Metrics
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