Journal article
The Predictive Potential of Elevated Serum Inflammatory Markers in Determining the Need for Intubation in CoVID-19 Patients
Journal of critical care medicine (Universitatea de Medicină și Farmacie din Târgu-Mureș), Vol.8(1), pp.14-22
01/01/2022
DOI: 10.2478/jccm-2021-0035
PMCID: PMC8852285
PMID: 35274051
Abstract
Introduction: The predictive potential of demographics, clinical characteristics, and inflammatory markers at admission to determine future intubation needs of hospitalised CoVID-19 patients is unknown. The study aimed to determine the predictive potential of elevated serum inflammatory markers in determining the need for intubation in CoVID-19 Patients. Methods: In a retrospective cohort study of hospitalised SARS-CoV2 positive patients, single and multivariable regression analyses were used to determine covariate effects on intubation odds, and a minimax concave penalty regularised logistic regression was used to build a predictive model. A second prospective independent cohort tested the model. Results: Systemic inflammatory markers obtained at admission were higher in patients that required subsequent intubation, and adjusted odds of intubation increased for every standard deviation above the mean for c-reactive protein (CRP) OR:2.8 (95% CI 1.8-4.5, p<0.001) and lactate dehydrogenase OR:2.1 (95% CI 1.33.3, p=0.002). A predictive model incorporating C-reactive protein, lactate dehydrogenase, and diabetes status at the time of admission predicted intubation status with an area under the curve (AUC) of 0.78 with corresponding sensitivity of 86%, specificity of 63%. This predictive model achieved an AUC of 0.83, 91% sensitivity, and 41% specificity on the validation cohort. Conclusion: In patients hospitalised with CoVID-19, elevated serum inflammatory markers measured within the first twenty-four hours of admission are associated with an increased need for intubation. Additionally, a model of C-reactive protein, lactate dehydrogenase, and the presence of diabetes may play a predictive role in determining the future need for intubation.
Details
- Title: Subtitle
- The Predictive Potential of Elevated Serum Inflammatory Markers in Determining the Need for Intubation in CoVID-19 Patients
- Creators
- Samuel Windham - Univ Colorado, Anschutz Med Campus, Denver, CO 80202 USAKellen Hirsch - University of Colorado Anschutz Medical CampusRyan Peterson - University of Colorado Anschutz Medical CampusDavid Douin - University of Colorado Anschutz Medical CampusLakshmi Chauhan - University of Colorado Anschutz Medical CampusLauren Heery - University of Colorado Anschutz Medical CampusConnor Fling - University of Colorado Anschutz Medical CampusNemanja Vukovic - University of Colorado Anschutz Medical CampusFernando Holguin - University of Colorado Anschutz Medical CampusShanta Zimmer - University of Colorado Anschutz Medical CampusKristine Erlandson - University of Colorado Anschutz Medical Campus
- Resource Type
- Journal article
- Publication Details
- Journal of critical care medicine (Universitatea de Medicină și Farmacie din Târgu-Mureș), Vol.8(1), pp.14-22
- DOI
- 10.2478/jccm-2021-0035
- PMID
- 35274051
- PMCID
- PMC8852285
- NLM abbreviation
- J Crit Care Med (Targu Mures)
- ISSN
- 2393-1809
- eISSN
- 2393-1817
- Publisher
- Sciendo
- Number of pages
- 9
- Grant note
- Pulmonary Translational Research Core (PTraC)
- Language
- English
- Date published
- 01/01/2022
- Academic Unit
- Biostatistics; Internal Medicine
- Record Identifier
- 9984914149402771
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