Journal article
The Prevalence of Metabolic and Endocrine Disturbances on Fracture Nonunion
Endocrine practice, Vol.28(6), pp.599-602
06/2022
DOI: 10.1016/j.eprac.2022.03.003
PMID: 35278705
Abstract
This study aims to determine the prevalence of metabolic disturbance in all fracture nonunion cases and identify the most common endocrine abnormalities seen using a simple screening algorithm.
A retrospective review study was performed evaluating patients who underwent operative intervention for nonunion from January 2010 to December 2018 at 2 level-1 trauma centers. Preoperative laboratory values were recorded for a 9-test “nonunion panel.” A metabolic or endocrine abnormality, specifically an abnormality in the thyroid or parathyroid axis, was evaluated.
42% of patients had an undiagnosed metabolic laboratory abnormality. When multiple tests were used, the rate of metabolic dysfunction was between 60% and 75%, depending on the definition of vitamin D insufficiency vs deficiency used.
Results indicate a relatively high prevalence of metabolic disturbance in patients with nonunion and suggest metabolic screening for all nonunion patients not only those without a mechanical or infectious cause.
IV, retrospective case series.
Details
- Title: Subtitle
- The Prevalence of Metabolic and Endocrine Disturbances on Fracture Nonunion
- Creators
- Patrick F. Bergin - University of Mississippi Medical CenterDavid L. Rothberg - University of UtahClay A. Spitler - University of Alabama at BirminghamBopha Chrea - Oregon Health & Science UniversityDaniel T. Miles - University of Tennessee at ChattanoogaUgur Yener - University of Mississippi Medical CenterEldrin Bhanat - University of Mississippi Medical CenterHunter G. Frederiksen - University of UtahMatt L. Graves - University of Mississippi Medical Center
- Resource Type
- Journal article
- Publication Details
- Endocrine practice, Vol.28(6), pp.599-602
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.eprac.2022.03.003
- PMID
- 35278705
- ISSN
- 1530-891X
- eISSN
- 1934-2403
- Language
- English
- Date published
- 06/2022
- Academic Unit
- Orthopedics and Rehabilitation
- Record Identifier
- 9984459632502771
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