Journal article
The Prevalence of Post-Acute Sequelae of COVID-19 in Solid Organ Transplant Recipients: Evaluation of Risk in the National COVID Cohort Collaborative (N3C)
American journal of transplantation, Vol.24(9), pp.1675-1689
09/2024
DOI: 10.1016/j.ajt.2024.06.001
PMCID: PMC11390303
PMID: 38857785
Abstract
Post-acute sequelae after COVID-19 (PASC) is increasingly recognized, though data in solid organ transplant recipients (SOTR) are limited. Using the N3C, we performed 1:1 propensity score matching (PSM) of all adult SOTR and non-immunosuppressed/immunocompromised (ISC) patients with acute COVID (08-01-2021 to 01-13-2023), for a subsequent PASC diagnosis using ICD-10-CM codes. Multivariable logistic regression was used to examine the association of SOT status with PASC, but also other patient factors after stratifying by SOT status. Prior to PSM, there were 8,769 SOT and 1,576,769 non-ISC patients with acute COVID. After PSM, 8,756 SOTR and 8,756 non-ISC patients were included; 2.2% of SOTR (n=192) and 1.4% (n=122) of non-ISC patients developed PASC (p-value<0.001). In the overall matched cohort, SOT was independently associated with PASC (aOR 1.48, 95% CI 1.09-2.01). Amongst SOTR, COVID severity (aOR 11.6, 95% CI 3.93-30.0 for severe versus mild disease), older age (aOR 1.02, 95% CI 1.01-1.03 per year), and mycophenolate mofetil use (aOR 2.04, 95% CI 1.38-3.05) were each independently associated with PASC. In non-ISC patients, only depression (aOR 1.96, 95% CI 1.24-3.07) and COVID severity were. In conclusion, PASC occurs more commonly in SOTR than non-ISC patients, with differences in risk profiles based on SOT status.
Details
- Title: Subtitle
- The Prevalence of Post-Acute Sequelae of COVID-19 in Solid Organ Transplant Recipients: Evaluation of Risk in the National COVID Cohort Collaborative (N3C)
- Creators
- Amanda J. Vinson - Dalhousie UniversityMakayla Schissel - Dalhousie UniversityAlfred J. Anzalone - University of Nebraska Medical CenterRan Dai - University of Nebraska Medical CenterEvan T. French - Virginia Commonwealth UniversityAmy L. Olex - Virginia Commonwealth UniversityStephen B. Lee - University of SaskatchewanMichael Ison - Division of Microbiology and Infectious Diseases, Rockville, MDRoslyn B. Mannon - University of Nebraska Medical CenterAdam B. Wilcox - Dalhousie UniversityAdam M. LeeAlexis GravesAmin MannaAmit SahaAmy OlexAndrea ZhouAndrew E. WilliamsAndrew SoutherlandAndrew T. GirvinAnita WaldenAnjali A. SharathkumarBenjamin AmorBenjamin BatesBrian HendricksBrijesh PatelCaleb AlexanderCarolyn BramanteCavin Ward-CavinessCharisse Madlock-BrownChristine SuverChristopher ChuteChristopher DillonChunlei WuClare SchmittCliff TakemotoDan HousmanDavera GabrielDavid A. EichmannDiego MazzottiDon BrownEilis BoudreauElaine HillElizabeth ZampinoEmily Carlson MartiEmily R. PfaffFarrukh M. KoraishyFederico MarionaFred PriorGeorge SokosGreg MartinHarold LehmannHeidi SprattHemalkumar MehtaHongfang LiuHythem SidkyJ.W. Awori HayangaJami PincavitchJaylyn ClarkJeremy Richard HarperJessica IslamJin GeJoel GagnierJoel H. SaltzJohanna LoombaJohn BuseJomol MathewJoni L. RutterJulie A. McMurryJustin GuinneyJustin StarrenKaren CrowleyKatie Rebecca BradwellKellie M. WaltersKen WilkinsKenneth R. GersingKenrick Dwain CatoKimberly MurrayKristin KostkaLavance NorthingtonLee Allan PylesLeonie MisquittaLesley CottrellLili PortillaMariam DeacyMark M. BissellMarshall ClarkMary EmmettMary Morrison SaltzMatvey B. PalchukMelissa A. HaendelMeredith AdamsMeredith Temple-O'ConnorMichael G. KurillaMichele MorrisNabeel QureshiNasia SafdarNicole GarbariniNoha SharafeldinOfer SadanPatricia A. FrancisPenny Wung BurgoonPeter RobinsonPhilip R.O. PayneRafael FuentesRandeep JawaRebecca Erwin-CohenRena PatelRichard A. MoffittRichard L. ZhuRishi KamaleswaranRobert HurleyRobert T. MillerSaiju PyarajanSam G. MichaelSamuel BozzetteSandeep MallipattuSatyanarayana VedulaScott ChapmanShawn T. O'NeilSoko SetoguchiStephanie S. HongSteve JohnsonTellen D. BennettTiffany CallahanUmit TopalogluUsman SheikhValery GordonVignesh SubbianWarren A. KibbeWenndy HernandezWill BeasleyWill CooperWilliam HillegassXiaohan Tanner ZhangNational COVID Cohort Collaborative
- Resource Type
- Journal article
- Publication Details
- American journal of transplantation, Vol.24(9), pp.1675-1689
- DOI
- 10.1016/j.ajt.2024.06.001
- PMID
- 38857785
- PMCID
- PMC11390303
- NLM abbreviation
- Am J Transplant
- ISSN
- 1600-6135
- eISSN
- 1600-6143
- Publisher
- Elsevier Inc; NEW YORK
- Grant note
- National Institute of General Medical Sciences: U54GM104942-05S2, U54GM115458
This study was supported by the National Institute of General Medical Sciences, U54GM104942-05S2 and U54GM115458. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National In-stitutes of Health or the N3C program.
- Language
- English
- Electronic publication date
- 06/08/2024
- Date published
- 09/2024
- Academic Unit
- School of Library and Information Science; Stead Family Department of Pediatrics; Hematology/Oncology; Nursing
- Record Identifier
- 9984643755702771
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