Journal article
The Purinosome: A Case Study for a Mammalian Metabolon
Annual review of biochemistry, Vol.91(1), pp.89-106
06/21/2022
DOI: 10.1146/annurev-biochem-032620-105728
PMCID: PMC9531488
PMID: 35320684
Abstract
Over the past fifteen years, we have unveiled a new mechanism by which cells achieve greater efficiency in de novo purine biosynthesis. This mechanism relies on the compartmentalization of de novo purine biosynthetic enzymes into a dynamic complex called the purinosome. In this review, we highlight our current understanding of the purinosome with emphasis on its biophysical properties and function and on the cellular mechanisms that regulate its assembly. We propose a model for functional purinosomes in which they consist of at least ten enzymes that localize near mitochondria and carry out de novo purine biosynthesis by metabolic channeling. We conclude by discussing challenges and opportunities associated with studying the purinosome and analogous metabolons.
Details
- Title: Subtitle
- The Purinosome: A Case Study for a Mammalian Metabolon
- Creators
- Anthony M. Pedley - Pennsylvania State UniversityVidhi Pareek - Pennsylvania State UniversityStephen J. Benkovic - Pennsylvania State University
- Resource Type
- Journal article
- Publication Details
- Annual review of biochemistry, Vol.91(1), pp.89-106
- DOI
- 10.1146/annurev-biochem-032620-105728
- PMID
- 35320684
- PMCID
- PMC9531488
- NLM abbreviation
- Annu Rev Biochem
- ISSN
- 0066-4154
- eISSN
- 1545-4509
- Publisher
- Annual Reviews
- Number of pages
- 18
- Grant note
- R01 GM024129 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA Huck Institutes of the Life Sciences at Penn State
- Language
- English
- Date published
- 06/21/2022
- Academic Unit
- Biochemistry and Molecular Biology
- Record Identifier
- 9984771654402771
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