Journal article
The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy
Radiology, Vol.294(3), pp.647-657
03/2020
DOI: 10.1148/radiol.2019191882
PMCID: PMC7053216
PMID: 31909700
Abstract
The Quantitative Imaging Biomarkers Alliance (QIBA) Profile for fluorodeoxyglucose (FDG) PET/CT imaging was created by QIBA to both characterize and reduce the variability of standardized uptake values (SUVs). The Profile provides two complementary claims on the precision of SUV measurements. First, tumor glycolytic activity as reflected by the maximum SUV (SUV
) is measurable from FDG PET/CT with a within-subject coefficient of variation of 10%-12%. Second, a measured increase in SUV
of 39% or more, or a decrease of 28% or more, indicates that a true change has occurred with 95% confidence. Two applicable use cases are clinical trials and following individual patients in clinical practice. Other components of the Profile address the protocols and conformance standards considered necessary to achieve the performance claim. The Profile is intended for use by a broad audience; applications can range from discovery science through clinical trials to clinical practice. The goal of this report is to provide a rationale and overview of the FDG PET/CT Profile claims as well as its context, and to outline future needs and potential developments.
Details
- Title: Subtitle
- The QIBA Profile for FDG PET/CT as an Imaging Biomarker Measuring Response to Cancer Therapy
- Creators
- Paul E Kinahan - University of WashingtonEric S Perlman - Perlman Advisory Group, LLCJohn J Sunderland - University of IowaRathan Subramaniam - RadiologyScott D Wollenweber - GE Healthcare, United States;Timothy G Turkington - Duke UniversityMartin A Lodge - Johns Hopkins UniversityRonald Boellaard - Department of Radiology and Nuclear MedicineNancy A Obuchowski - Cleveland ClinicRichard L Wahl - Mallinckrodt
- Resource Type
- Journal article
- Publication Details
- Radiology, Vol.294(3), pp.647-657
- DOI
- 10.1148/radiol.2019191882
- PMID
- 31909700
- PMCID
- PMC7053216
- ISSN
- 0033-8419
- eISSN
- 1527-1315
- Grant note
- U01 CA190254 / NCI NIH HHS HHSN268201000050C / NIBIB NIH HHS R01 CA169072 / NCI NIH HHS HHSN268201300071C / NIBIB NIH HHS HHSN268201500021C / NHLBI NIH HHS U01 CA148131 / NCI NIH HHS
- Language
- English
- Date published
- 03/2020
- Academic Unit
- Radiology; Physics and Astronomy; Radiation Oncology
- Record Identifier
- 9984312973502771
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