The RAM network in pathogenic fungi

Sarah Saputo; Yeissa Chabrier-Rosello; Francis C Luca; Anuj Kumar; Damian J Krysan

doi:10.1128/EC.00044-12

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The RAM network in pathogenic fungi

Sarah Saputo, Yeissa Chabrier-Rosello, Francis C Luca, Anuj Kumar and Damian J Krysan

Eukaryotic cell, Vol.11(6), pp.708-717

06/2012

DOI: 10.1128/EC.00044-12

PMCID: PMC3370468

PMID: 22544903

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Abstract

The regulation of Ace2 and morphogenesis (RAM) network is a protein kinase signaling pathway conserved among eukaryotes from yeasts to humans. Among fungi, the RAM network has been most extensively studied in the model yeast Saccharomyces cerevisiae and has been shown to regulate a range of cellular processes, including daughter cell-specific gene expression, cell cycle regulation, cell separation, mating, polarized growth, maintenance of cell wall integrity, and stress signaling. Increasing numbers of recent studies on the role of the RAM network in pathogenic fungal species have revealed that this network also plays an important role in the biology and pathogenesis of these organisms. In addition to providing a brief overview of the RAM network in S. cerevisiae, we summarize recent developments in the understanding of RAM network function in the human fungal pathogens Candida albicans, Candida glabrata, Cryptococcus neoformans, Aspergillus fumigatus, and Pneumocystis spp.

DNA-Binding Proteins - metabolism

Morphogenesis

Protein Kinases - metabolism

Transcription Factors - metabolism

Signal Transduction

Humans

Fungi - enzymology

Saccharomyces cerevisiae Proteins - metabolism

Saccharomyces cerevisiae - enzymology

Fungi - growth & development

Saccharomyces cerevisiae - growth & development

Fungal Proteins - metabolism

Details

Title: Subtitle: The RAM network in pathogenic fungi
Creators: Sarah Saputo - Department of Microbiology/Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Yeissa Chabrier-Rosello
Francis C Luca
Anuj Kumar
Damian J Krysan
Resource Type: Journal article
Publication Details: Eukaryotic cell, Vol.11(6), pp.708-717
DOI: 10.1128/EC.00044-12
PMID: 22544903
PMCID: PMC3370468
NLM abbreviation: Eukaryot Cell
ISSN: 1535-9778
eISSN: 1535-9786
Publisher: American Society for Microbiology
Grant note: T90 DE021985 / NIDCR NIH HHS R21 AI084539 / NIAID NIH HHS R01 AI098450 / NIAID NIH HHS 1R01AI098450-1A1 / NIAID NIH HHS T32 AI007464 / NIAID NIH HHS 5T32AI007464 / NIAID NIH HHS 5R21AI084539 / NIAID NIH HHS
Language: English
Date published: 06/2012
Academic Unit: Microbiology and Immunology; Stead Family Department of Pediatrics; Infectious Disease (Pediatrics)
Record Identifier: 9984093235102771

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