The Relationship Between Brain Structure and Cognition in Transfused Preterm Children at School Age

Thomasin E McCoy; Amy L Conrad; Lynn C Richman; Jane E Brumbaugh; Vincent A Magnotta; Edward F Bell; Peggy C Nopoulos

doi:10.1080/87565641.2013.874428

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The Relationship Between Brain Structure and Cognition in Transfused Preterm Children at School Age

Journal article

Peer reviewed

The Relationship Between Brain Structure and Cognition in Transfused Preterm Children at School Age

Thomasin E McCoy, Amy L Conrad, Lynn C Richman, Jane E Brumbaugh, Vincent A Magnotta, Edward F Bell and Peggy C Nopoulos

Developmental neuropsychology, Vol.39(3), pp.226-232

04/03/2014

DOI: 10.1080/87565641.2013.874428

PMCID: PMC4071071

PMID: 24742312

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http://doi.org/10.1080/87565641.2013.874428View

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Abstract

Examine the relationship between brain structure and cognition in preterm children randomly assigned to a liberal red blood cell (RBC) transfusion strategy as neonates. Intelligence, achievement, and neuropsychological measures were assessed and structural imaging was obtained (n = 26; 38% male). Global brain volumes were related to cognitive outcome. Additionally, females performed lower on verbal fluency; lower performance was related to temporal white matter volume. Findings provide possible evidence of the adverse effect of a liberal RBC transfusion strategy in which females had decreased temporal lobe white matter directly related to poor verbal fluency.

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Title: Subtitle: The Relationship Between Brain Structure and Cognition in Transfused Preterm Children at School Age
Creators: Thomasin E McCoy - Hope Springs Behavioral Consultants, PLC (Private Practice)
Amy L Conrad - Departments of Psychiatry and Pediatrics, University of Iowa
Lynn C Richman - Department of Pediatrics, University of Iowa
Jane E Brumbaugh - Department of Pediatrics, University of Iowa
Vincent A Magnotta - Department of Radiology, University of Iowa
Edward F Bell - Department of Pediatrics, University of Iowa
Peggy C Nopoulos - Departments of Psychiatry and Pediatrics, University of Iowa
Resource Type: Journal article
Publication Details: Developmental neuropsychology, Vol.39(3), pp.226-232
DOI: 10.1080/87565641.2013.874428
PMID: 24742312
PMCID: PMC4071071
NLM abbreviation: Dev Neuropsychol
ISSN: 8756-5641
eISSN: 1532-6942
Publisher: Psychology Press
Language: English
Date published: 04/03/2014
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Neonatology
Record Identifier: 9984051563702771

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