The Relationship Between Diabetes, Diabetes Severity, Diabetes Biomarkers, and the Presence of Lower Urinary Tract Symptoms: Findings From the National Health and Nutrition Examination Survey

Christopher A Tam; Brian T Helfand; Bradley A Erickson

doi:10.1016/j.urology.2017.03.040

Back

The Relationship Between Diabetes, Diabetes Severity, Diabetes Biomarkers, and the Presence of Lower Urinary Tract Symptoms: Findings From the National Health and Nutrition Examination Survey

Journal article

Open access

Peer reviewed

The Relationship Between Diabetes, Diabetes Severity, Diabetes Biomarkers, and the Presence of Lower Urinary Tract Symptoms: Findings From the National Health and Nutrition Examination Survey

Christopher A Tam, Brian T Helfand and Bradley A Erickson

Urology (Ridgewood, N.J.), Vol.105, pp.141-148

07/2017

DOI: 10.1016/j.urology.2017.03.040

PMCID: PMC6317346

PMID: 28392180

Files and links (1)

url

https://doi.org/10.1016/j.urology.2017.03.040View

Published (Version of record) Open Access

Abstract

To characterize the associations between diabetes mellitus (DM) and lower urinary tract symptoms (LUTS). This study focuses on the relationships between specific diabetic characteristics (eg, severity, biomarkers) and the prevalence of LUTS. The 2005-2008 cycles of the National Health and Nutrition Examination Survey were queried for men who completed both a DM and a kidney/prostate questionnaire. Men with LUTS were defined as those experiencing at least 1 out of 3 of the following: nocturia, hesitancy, or incomplete emptying. Men with DM were defined as having been diagnosed by a physician and being actively treated. Multivariate logistic regression with sample weighting was performed to assess effects of biomarker levels (HgbA1c, fasting glucose), medication use, and surrogates of disease progression on the presence of LUTS. Of the 2127 male participants, those with DM (n = 405) were more likely to experience at least 1 urinary symptom (adjusted odds ratio 1.63, P <.0001). Men under the age of 70 with long-standing (>5 years) DM were more likely to report LUTS than those with a shorter duration of the disease (<5 years). Diabetes-specific biomarkers (HgbA1c, fasting glucose) were not predictors of LUTS in men with DM. DM was confirmed to be strongly associated with patient-reported LUTS in men. Younger men and those with longer-standing disease appear to be most susceptible. In actively treated patients with DM, DM biomarkers were not helpful in predicting individual LUTS. Instead, biomarkers that indirectly reflect DM disease progression were most useful.

Severity of Illness Index

Prevalence

Nutrition Surveys

United States

Glycated Hemoglobin A - metabolism

Humans

Middle Aged

Logistic Models

Male

Lower Urinary Tract Symptoms - epidemiology

Biomarkers - blood

Diabetes Complications - therapy

Diabetes Complications - blood

Diabetes Complications - complications

Health Behavior

Prostate-Specific Antigen - blood

Lower Urinary Tract Symptoms - blood

Adult

Aged

Blood Glucose - metabolism

Details

Title: Subtitle: The Relationship Between Diabetes, Diabetes Severity, Diabetes Biomarkers, and the Presence of Lower Urinary Tract Symptoms: Findings From the National Health and Nutrition Examination Survey
Creators: Christopher A Tam - University of Iowa Carver College of Medicine, Iowa City, IA
Brian T Helfand - Northshore University Health System, Chicago, IL
Bradley A Erickson - University of Iowa Carver College of Medicine, Iowa City, IA. Electronic address: brad-erickson@uiowa.edu
Resource Type: Journal article
Publication Details: Urology (Ridgewood, N.J.), Vol.105, pp.141-148
DOI: 10.1016/j.urology.2017.03.040
PMID: 28392180
PMCID: PMC6317346
NLM abbreviation: Urology
ISSN: 0090-4295
eISSN: 1527-9995
Publisher: United States
Grant note: T35 HL007485 / NHLBI NIH HHS
Language: English
Date published: 07/2017
Academic Unit: Urology
Record Identifier: 9984051530002771

Metrics

13 Record Views

25 Times Cited - Web of Science