The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment

Xiwu Wang; Wenjun Zhou; Teng Ye; Xiaodong Lin; Jie Zhang; Alzheimer’s Disease Neuroimaging Initiative

doi:10.3389/fnagi.2019.00036

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The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment

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The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment

Xiwu Wang, Wenjun Zhou, Teng Ye, Xiaodong Lin, Jie Zhang and Alzheimer’s Disease Neuroimaging Initiative

Frontiers in aging neuroscience, Vol.11, 36

01/01/2019

DOI: 10.3389/fnagi.2019.00036

PMCID: PMC6399520

PMID: 30863302

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Abstract

Objective: To investigate whether APOE ε4 affects the association of verbal memory with neurodegeneration presented by the hippocampal volume/intracranial volume ratio (HpVR). Methods: The study sample included 371 individuals with normal cognition (NC), 725 subjects with amnestic mild cognitive impairment (aMCI), and 251 patients with mild Alzheimer's disease (AD) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) who underwent the rey auditory verbal learning test (RAVLT). Multiple linear regression models were conducted to assess the effect of the APOE ε4∗HpVR interaction on RAVLT in all subjects and in each diagnostic group adjusting for age, gender and educational attainment, and global cognition. Results: In all subjects, there was no significant APOE ε4 × HpVR interaction for immediate recall or delayed recall (p > 0.05). However, in aMCI subjects, there was a significant APOE ε4 × HpVR interaction for delayed recall (p = 0.008), but not immediate recall (p = 0.15). More specifically, the detrimental effect of APOE ε4 on delayed recall altered by HpVR such that this effect was most evident among subjects with small to moderate HpVR, but this disadvantage was absent or even reversed among subjects with larger HpVR. No significant interaction was observed in the NC or AD group. Conclusion: These findings highlight a potential role of APOE ε4 status in affecting the association of hippocampus size with delayed recall memory in the early stage of AD.

Aging

Brain Disorders

Dementia

2.1 Biological and endogenous factors

Acquired Cognitive Impairment

Alzheimer's disease

Alzheimer's Disease including Alzheimer's Disease Related Dementias

Alzheimer’s Disease Neuroimaging Initiative

amnestic mild cognitive impairment

APOE epsilon 4

APOE ε4

Behavioral and Social Science

Biochemistry and Cell Biology

Cognitive Sciences

episodic memory

hippocampus

Neurodegenerative

Neurological

Neurosciences

Details

Title: Subtitle: The Relationship Between Hippocampal Volumes and Delayed Recall Is Modified by APOE ε4 in Mild Cognitive Impairment
Creators: Xiwu Wang
Wenjun Zhou - Hangzhou Normal University
Teng Ye
Xiaodong Lin
Jie Zhang
Alzheimer’s Disease Neuroimaging Initiative
Contributors: Del D Miller (Contributor) - University of Iowa, Psychiatry
HyungSub Shim (Contributor) - University of Iowa, Neurology
Susan K Schultz (Contributor) - University of Iowa, Psychiatry
Hristina K Koleva (Contributor) - University of Iowa, Psychiatry
Resource Type: Journal article
Publication Details: Frontiers in aging neuroscience, Vol.11, 36
DOI: 10.3389/fnagi.2019.00036
PMID: 30863302
PMCID: PMC6399520
NLM abbreviation: Front Aging Neurosci
ISSN: 1663-4365
Language: English
Date published: 01/01/2019
Academic Unit: Neurology; Psychiatry
Record Identifier: 9984287154702771

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