Journal article
The Relationship Between Serum 25-Hydroxyvitamin D Levels and Nuclear Cataract in the Carotenoid Age-Related Eye Study (CAREDS), an Ancillary Study of the Women's Health Initiative
Investigative ophthalmology & visual science, Vol.56(8), pp.4221-4230
07/2015
DOI: 10.1167/iovs.15-16835
PMCID: PMC4495813
PMID: 26132781
Abstract
To investigate the relationship between serum 25-hydroxyvitamin D (25[OH]D) levels and nuclear cataract among participants of the Carotenoids in Age-Related Eye Disease Study (CAREDS), an ancillary study of the Women's Health Initiative (WHI) Observational Study (OS).
Nuclear cataract was assessed from slit lamp photographs (2001-2004) taken 6 years after collecting serum analyzed for 25(OH)D levels at WHI baseline (1994-1998) in 1278 CAREDS participants age 50 to 79 years. Multivariate (age, iris color, smoking, pulse pressure) odds ratios (ORs) for nuclear cataract (nuclear opacities > level 4 or cataract extraction) by quintiles of serum 25(OH)D were estimated using logistic regression.
No significant association was observed between serum 25(OH)D and nuclear cataract among women of all ages (age-adjusted OR [95% confidence interval (CI)] 0.97 [0.65-1.45]). However, there was a significant age interaction (P for interaction = 0.04). There were no significant associations in the women 70 years or older. In women younger than 70 years, we observed an inverse association between serum 25(OH)D and nuclear cataract (multivariate adjusted ORs [95% CI] 0.54 [0.29-0.99] and 0.66 [0.36-1.20] for quintiles 4 and 5 vs. 1, respectively; P = 0.03). Further adjustment for 25(OH)D determinants (body mass index, vitamin D intake, and UVB exposure) attenuated this association.
Serum 25(OH)D levels were unrelated to nuclear opacities in this study sample. However, exploratory analyses suggest a protective association in women younger than 70 years. Further investigations of the relationship between vitamin D and nuclear lens opacities are warranted.
Details
- Title: Subtitle
- The Relationship Between Serum 25-Hydroxyvitamin D Levels and Nuclear Cataract in the Carotenoid Age-Related Eye Study (CAREDS), an Ancillary Study of the Women's Health Initiative
- Creators
- Prethy Rao - Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, Wisconsin, United StatesAmy E Millen - Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, The State University of New York, Buffalo, New York, United StatesKristin J Meyers - Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, Wisconsin, United StatesZhe Liu - Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, Wisconsin, United StatesRickie Voland - Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, Wisconsin, United StatesSheri Sondel - University of Wisconsin CollegesLesley Tinker - Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United StatesRobert B Wallace - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United StatesBarbara A Blodi - Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, Wisconsin, United StatesNeil Binkley - Department of Medicine, University of Wisconsin, Madison, Wisconsin, United StatesGloria Sarto - Department of Obstetrics and Gynecology, University of Wisconsin, Madison, Wisconsin, United StatesJennifer Robinson - Department of Epidemiology, University of Iowa, Iowa City, Iowa, United StatesErin LeBlanc - Kaiser Permanente Center for Health Research, Portland, Oregon, United StatesJulie A Mares - Department of Ophthalmology and Visual Sciences University of Wisconsin, Madison, Wisconsin, United States
- Resource Type
- Journal article
- Publication Details
- Investigative ophthalmology & visual science, Vol.56(8), pp.4221-4230
- DOI
- 10.1167/iovs.15-16835
- PMID
- 26132781
- PMCID
- PMC4495813
- NLM abbreviation
- Invest Ophthalmol Vis Sci
- ISSN
- 0146-0404
- eISSN
- 1552-5783
- Publisher
- United States
- Grant note
- HHSN268201100002I / NHLBI NIH HHS HHSN271201100004C / NIA NIH HHS HHSN268201100046C / PHS HHS HHSN268201100001C / WHI NIH HHS HHSN268201100004I / NHLBI NIH HHS P30 CA015704 / NCI NIH HHS EY016886 / NEI NIH HHS R01 EY016886 / NEI NIH HHS EY013018 / NEI NIH HHS HHSN271201100004C / PHS HHS HHSN268201100004C / WHI NIH HHS HHSN2 6 8 2 0 1 1 0 0 0 0 2 C / PHS HHS HHSN268201100046C / NHLBI NIH HHS U10 EY013018 / NEI NIH HHS HHSN268201100002C / WHI NIH HHS HHSN268201100001I / NHLBI NIH HHS HHSN268201100004C / PHS HHS HHS N 2 6 8 2 0 1 1 0 0 0 0 3 C / PHS HHS HHSN268201100003C / WHI NIH HHS HHSN268201100001C / PHS HHS
- Language
- English
- Date published
- 07/2015
- Academic Unit
- Epidemiology; Fraternal Order of Eagles Diabetes Research Center; Injury Prevention Research Center; Internal Medicine
- Record Identifier
- 9983996099002771
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