The Relationship between blood pressure parameters and left ventricular output in neonates

Ashraf Kharrat; Regan E Giesinger; Daniel Ibarra Rios; Patrick J McNamara; Dany E Weisz; Alan Groves; Junmin Yang; Prakesh S Shah; Amish Jain

doi:10.1038/s41372-019-0337-6

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The Relationship between blood pressure parameters and left ventricular output in neonates

Journal article

Peer reviewed

The Relationship between blood pressure parameters and left ventricular output in neonates

Ashraf Kharrat, Regan E Giesinger, Daniel Ibarra Rios, Patrick J McNamara, Dany E Weisz, Alan Groves, Junmin Yang, Prakesh S Shah and Amish Jain

Journal of perinatology, Vol.39(5), pp.619-625

05/2019

DOI: 10.1038/s41372-019-0337-6

PMID: 30770881

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Abstract

To evaluate the relationship between systolic (SBP), diastolic (DBP), mean (MBP) blood pressures and pulse pressure (PP), and left ventricular output (LVO), a surrogate of systemic blood flow. This retrospective study included neonates who underwent targeted neonatal echocardiography (TNE) in 3-tertiary NICUs over 2 years. Associations between LVO and BP components were investigated. Analysis was adjusted for relevant covariates. 1060 studies from 485 neonates were included, with a mean GA of 28.4 ± 4.6 weeks and birth weight of 1234 ± 840 grams. LVO was associated positively with SBP and PP, and negatively with GA. PP demonstrated the highest predictive value for identifying infants with LVO < 150 ml/kg/min (area under the curve 0.75 [95% CI 0.68, 0.82]). MBP and DBP demonstrated no correlation with LVO. BP parameters correlate poorly with LVO, irrespective of GA and underlying etiology. Narrow PP may be more reflective of low LVO than low SBP.

Blood Pressure

Infant, Extremely Low Birth Weight

Ventricular Function, Left

Humans

Cardiac Output

Male

Intensive Care Units, Neonatal

Echocardiography, Doppler

Female

Infant, Extremely Premature

ROC Curve

Retrospective Studies

Ontario

Blood Pressure Determination

Infant, Newborn

Details

Title: Subtitle: The Relationship between blood pressure parameters and left ventricular output in neonates
Creators: Ashraf Kharrat - Department of Paediatrics, University of Toronto, Toronto, ON, Canada
Regan E Giesinger - Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada
Daniel Ibarra Rios - Neonatology Department, Hospital Infantil de México Federico Gómez, National Institute of Health, Mexico City, Mexico
Patrick J McNamara - Division of Neonatology, The Hospital for Sick Children, Toronto, ON, Canada
Dany E Weisz - Newborn and Developmental Paediatrics, Sunnybrook Health Sciences Centre, Toronto, ON, Canada
Alan Groves - Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA
Junmin Yang - MiCare Research Center, Mount Sinai Hospital, Toronto, ON, Canada
Prakesh S Shah - Department of Paediatrics and Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada
Amish Jain - Department of Paediatrics and Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON, Canada. amish.jain@sinaihealthsystem.ca
Resource Type: Journal article
Publication Details: Journal of perinatology, Vol.39(5), pp.619-625
DOI: 10.1038/s41372-019-0337-6
PMID: 30770881
ISSN: 0743-8346
eISSN: 1476-5543
Language: English
Date published: 05/2019
Academic Unit: Stead Family Department of Pediatrics; Neonatology; Internal Medicine
Record Identifier: 9984093476702771

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