Journal article
The Relationship of Cardiovascular Disease to Physical Functioning in Women Surviving to Age 80 and Above in the Women's Health Initiative
The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.71 Suppl 1(3), pp.S42-S53
03/2016
DOI: 10.1093/gerona/glv087
PMCID: PMC5865536
PMID: 26858324
Abstract
Cardiovascular disease (CVD) is highly prevalent at ages 80 and above. The association of physical functioning (PF), a key to an optimal aging trajectory, with CVD and specific CVD diagnosis in women who survive to age 80 and above has not been described previously and has important public health significance given our aging population.
Women's Health Initiative participants aged 80 years or older at the time of self-reporting PF (RAND SF-36) were studied in relationship to CVD diagnosis, whether present at study baseline (1993-1998) or diagnosed during follow-up through 2012. Cross-sectional analyses utilized demographic, medical, lifestyle, and psycho-social questionnaire data from baseline or updated at the time of self-reported PF.
Among 27,145 older Women's Health Initiative participants, 22.0% (N = 5,959) had been diagnosed with CVD, specifically: 11.3% (N = 3,071) with coronary heart disease; 4.7% (N = 1,279), stroke; 5.2% (N = 1,397), venous thromboembolism; 2.7% (N = 737), peripheral arterial disease; and 2.7% (N = 725), congestive heart failure. PF scores (mean ± SE) were significantly (p < .0001) higher without CVD (60.0 ± 26.9), compared with any CVD (47.9 ± 27.3), and for each specific CVD diagnosis: coronary heart disease (48.8 ± 27.1); stroke (44.8 ± 27.9); venous thromboembolism (48.9 ± 27.4); peripheral arterial disease (41.9 ± 2.2); and congestive heart failure (38.8 ± 26.1). Regardless of CVD diagnosis, higher PF was associated with: younger age at the time of PF assessment; lower body mass index; higher recreational physical activity; better self-reported general health; fewer hip fractures after age 55; no history of arthritis; and no recent use of non-steroidal anti-inflammatory drugs.
Older women with any CVD, and particularly women with congestive heart failure or peripheral arterial disease, reported significantly lower PF compared to women with no CVD. Regardless of CVD diagnosis, higher PF was strongly associated with a more active lifestyle and lower body mass index, suggesting potential intervention targets for more optimal aging.
Details
- Title: Subtitle
- The Relationship of Cardiovascular Disease to Physical Functioning in Women Surviving to Age 80 and Above in the Women's Health Initiative
- Creators
- Marcia L Stefanick - Department of Medicine, Stanford Prevention Research Center and Department of Obstetrics & Gynecology, School of Medicine, Stanford University, California. stefanick@stanford.eduRobert L Brunner - Department of Family and Community Medicine, University of Nevada School of Medicine, RenoX Leng - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaMarian C Limacher - Division of Cardiovascular Medicine, Department of Medicine, College of Medicine, University of Florida, GainesvilleChloe E Bird - RAND Corporation, Santa Monica, CaliforniaDavid O Garcia - University of ArizonaPatricia E Hogan - Department of Biostatistical Sciences, Wake Forest School of Medicine, Winston-Salem, North CarolinaMichael J LaMonte - Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo - SUNY, New YorkRachel H Mackey - Department of Epidemiology, School of Public Health, University of Pittsburgh, PennsylvaniaKaren C Johnson - Department of Preventive Medicine, University of Tennessee Health Science Center, MemphisAndrea LaCroix - Department of Family and Preventative Medicine, University of California San Diego, La Jolla, CaliforniaJennifer G Robinson - Department of Epidemiology, College of Public Health, University of IowaRebecca A Seguin - Division of Nutritional Sciences, Cornell University, Ithica, New YorkHilary A Tindle - Center for Research on Health Care, University of Pittsburgh, PennsylvaniaSylvia Wassertheil-Smoller - Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York
- Resource Type
- Journal article
- Publication Details
- The journals of gerontology. Series A, Biological sciences and medical sciences, Vol.71 Suppl 1(3), pp.S42-S53
- Publisher
- United States
- DOI
- 10.1093/gerona/glv087
- PMID
- 26858324
- PMCID
- PMC5865536
- ISSN
- 1079-5006
- eISSN
- 1758-535X
- Grant note
- 24152 / PHS HHS 32108-9 / PHS HHS P30 AG021332 / NIA NIH HHS 32105-6 / PHS HHS 32122 / PHS HHS 32111-13 / PHS HHS 32115 / PHS HHS 42129-32 / PHS HHS 44221 / PHS HHS R25 CA078447 / NCI NIH HHS 32100-2 / PHS HHS Intramural NIH HHS 42107-26 / PHS HHS 32118-32119 / PHS HHS N01WH22110 / WHI NIH HHS
- Language
- English
- Date published
- 03/2016
- Academic Unit
- Epidemiology; Internal Medicine
- Record Identifier
- 9983995130102771
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