Journal article
The Relationship of Deiodinase 1 Genotype and Thyroid Function to Lifetime History of Major Depression in Three Independent Populations
American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.156(5), pp.593-599
07/2011
DOI: 10.1002/ajmg.b.31200
PMCID: PMC3236034
PMID: 21563302
Abstract
Major depression (MD) is often associated with disturbances of the hypothalamic/pituitary/thyroid (HPT) axis. Unfortunately, whether this association is secondary to common underlying genetic variation or whether the MD-associated disturbances in HPT function are chronic or state-dependent is unknown. To examine these questions, we genotyped 12 single nucleotide polymorphisms identified in previous genome wide association analyses of thyroid function in DNA contributed by 1555 subjects from three longitudinal ethnically diverse studies that are well-characterized for lifetime major depression and thyroid function. We then examined associations between genetic variants and key outcomes of thyroid stimulating hormone (TSH), free thyroxine (FT4) and depression. We confirmed prior findings that two variants in
deiodinase 1
(
DIO1
), including a variant in the 3’ UTR of
DIO1
(rs11206244), were associated with altered free thyroxine (FT4) levels in both White and African American subjects. We also found that rs11206244 genotype was associated with lifetime MD in White female subjects, in particular those from high-risk cohorts. However, we found no association of current FT4 levels with lifetime MD in either ethnic group. We conclude that genetic variation influencing thyroid function is a risk factor for MD. Given the evidence from prior studies, further investigations of role of HPT variation in etiology and treatment of MD are indicated.
Details
- Title: Subtitle
- The Relationship of Deiodinase 1 Genotype and Thyroid Function to Lifetime History of Major Depression in Three Independent Populations
- Creators
- Robert A Philibert - Iowa State University, Ames, IASteven R. H Beach - Iowa State University, Ames, IATracy D Gunter - Iowa State University, Ames, IAAlexandre A Todorov - Iowa State University, Ames, IAGene H Brody - Iowa State University, Ames, IAMeeshanthini Vijayendran - Iowa State University, Ames, IALilly Elliott - Iowa State University, Ames, IANancy Hollenbeck - Iowa State University, Ames, IADaniel Russell - Iowa State University, Ames, IACarolyn Cutrona - Iowa State University, Ames, IA
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics. Part B, Neuropsychiatric genetics, Vol.156(5), pp.593-599
- DOI
- 10.1002/ajmg.b.31200
- PMID
- 21563302
- PMCID
- PMC3236034
- NLM abbreviation
- Am J Med Genet B Neuropsychiatr Genet
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- Grant note
- R01 DA015789-05 || DA / National Institute on Drug Abuse : NIDA P30 DA027827-03 || DA / National Institute on Drug Abuse : NIDA
- Language
- English
- Date published
- 07/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003901402771
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