The Relationship of Exposure to Anesthesia on Outcomes in Children With Isolated Oral Clefts

Amy L Conrad; Jon W Goodwin; James Choi; Robert I Block; Peg Nopoulos

doi:10.1177/0883073816681257

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The Relationship of Exposure to Anesthesia on Outcomes in Children With Isolated Oral Clefts

Journal article

Peer reviewed

The Relationship of Exposure to Anesthesia on Outcomes in Children With Isolated Oral Clefts

Amy L Conrad, Jon W Goodwin, James Choi, Robert I Block and Peg Nopoulos

Journal of child neurology, Vol.32(3), pp.308-315

03/2017

DOI: 10.1177/0883073816681257

PMCID: PMC5312661

PMID: 28193114

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http://doi.org/10.1177/0883073816681257View

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Abstract

This study evaluated the relationship between exposure to anesthesia and previously identified differences in cognitive functioning, growth, and volumetric brain measures among a sample of children, adolescents, and young adults with isolated oral clefts. Data from a cross-sectional study were combined with a retrospective chart review. Data were obtained for 87 participants with isolated cleft lip and/or palate (55% male), ranging from 7.5 to 27 years old (mean = 15.78, standard deviation = 4.58). Measures of interest included cognitive functioning, growth measures, and brain volumes. Number of surgeries and time under anesthesia were obtained through systematic medical record review. Potential sex and cleft type differences in exposure as well as relationships between anesthesia exposure and outcome measures were evaluated. Participants with isolated cleft lip and palate had more surgeries and were under anesthesia longer. For participants with isolated cleft lip only, more surgeries were correlated to lower verbal IQ and higher frontal lobe volume.

Brain - diagnostic imaging

Cleft Lip - psychology

Humans

Male

Organ Size - physiology

Cleft Palate - psychology

Neuropsychological Tests

Young Adult

Magnetic Resonance Imaging

Cleft Lip - pathology

Cleft Palate - pathology

Adolescent

Brain - pathology

Cognition - physiology

Adult

Anesthesia

Cleft Lip - diagnostic imaging

Female

Retrospective Studies

Cleft Palate - diagnostic imaging

Child

Details

Title: Subtitle: The Relationship of Exposure to Anesthesia on Outcomes in Children With Isolated Oral Clefts
Creators: Amy L Conrad - 1 The Stead Family Department of Pediatrics, University of Iowa College of Medicine, Iowa city, IA, USA
Jon W Goodwin - 2 Department of Psychological & Quantitative Foundations, University of Iowa, Iowa city, IA, USA
James Choi - 3 Department of Anesthesia, University of Iowa College of Medicine, Iowa city, IA, USA
Robert I Block - 3 Department of Anesthesia, University of Iowa College of Medicine, Iowa city, IA, USA
Peg Nopoulos - 4 Department of Psychiatry, University of Iowa College of Medicine, Iowa city, IA, USA
Resource Type: Journal article
Publication Details: Journal of child neurology, Vol.32(3), pp.308-315
DOI: 10.1177/0883073816681257
PMID: 28193114
PMCID: PMC5312661
NLM abbreviation: J Child Neurol
ISSN: 0883-0738
eISSN: 1708-8283
Publisher: United States
Grant note: R01 DE014399 / NIDCR NIH HHS K23 DE024511 / NIDCR NIH HHS
Language: English
Date published: 03/2017
Academic Unit: Neurology; Psychiatry; Pediatric Psychology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Craniofacial Anomalies Research Center; Anesthesia; Psychological and Quantitative Foundations; Medicine Administration
Record Identifier: 9984007162202771

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