Journal article
The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging
Genes, Vol.11(12), pp.1-12
11/27/2020
DOI: 10.3390/genes11121415
PMCID: PMC7760261
PMID: 33260961
Abstract
Smoking is the largest preventable cause of mortality and the largest environmental driver of epigenetic aging. Contingency management-based strategies can be used to treat smoking but require objective methods of verifying quitting status. Prior studies have suggested that cg05575921 methylation reverts as a function of smoking cessation, but that it can be used to verify the success of smoking cessation has not been unequivocally demonstrated. To test whether methylation can be used to verify cessation, we determined monthly cg05575921 levels in a group of 67 self-reported smokers undergoing biochemically monitored contingency management-based smoking cessation therapy, as part of a lung imaging protocol. A total of 20 subjects in this protocol completed three months of cotinine verified smoking cessation. In these 20 quitters, the reversion of cg05575921 methylation was dependent on their initial smoking intensity, with methylation levels in the heaviest smokers reverting to an average of 0.12% per day over the 3-month treatment period. In addition, we found suggestive evidence that some individuals may have embellished their smoking history to gain entry to the study. Given the prominent effect of smoking on longevity, we conclude that DNA methylation may be a useful tool for guiding and incentivizing contingency management-based approaches for smoking cessation.
Details
- Title: Subtitle
- The Reversion of cg05575921 Methylation in Smoking Cessation: A Potential Tool for Incentivizing Healthy Aging
- Creators
- Robert Philibert - Behavioral Diagnostics LLC, Coralville, IA 52241, USAJames A Mills - Department of Psychiatry, University of Iowa, Iowa City, IA 52242, USAJeffrey D Long - Department of Biostatistics, University of Iowa, Iowa City, IA 52242, USASue Ellen Salisbury - Department of Radiology, University of Iowa, Iowa City, IA 52242, USAAlejandro Comellas - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USAAlicia Gerke - Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USAKelsey Dawes - Molecular Medicine Program, University of Iowa, Iowa City, IA 52242, USAMark Vander Weg - Center for Access & Delivery Research and Evaluation, Iowa City VA Health Care System, Iowa City, IA 52242, USAEric A Hoffman - Department of Radiology, University of Iowa, Iowa City, IA 52242, USA
- Resource Type
- Journal article
- Publication Details
- Genes, Vol.11(12), pp.1-12
- DOI
- 10.3390/genes11121415
- PMID
- 33260961
- PMCID
- PMC7760261
- NLM abbreviation
- Genes (Basel)
- eISSN
- 2073-4425
- Publisher
- Switzerland
- Grant note
- P30 ES005605 / NIEHS NIH HHS 5R01HL130883, R44CA213507 / NIH HHS
- Language
- English
- Date published
- 11/27/2020
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; Psychiatry; ICTS; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biostatistics; Injury Prevention Research Center; Community and Behavioral Health; Internal Medicine
- Record Identifier
- 9984070217702771
Metrics
58 Record Views