The Role of ANK in Calcium Pyrophosphate Deposition Disease

Elizabeth Mitton-Fitzgerald; Claudia M Gohr; Brittany Bettendorf; Ann K Rosenthal

doi:10.1007/s11926-016-0574-z

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Journal article

The Role of ANK in Calcium Pyrophosphate Deposition Disease

Elizabeth Mitton-Fitzgerald, Claudia M Gohr, Brittany Bettendorf and Ann K Rosenthal

Current rheumatology reports, Vol.18(5), pp.25-6

05/2016

DOI: 10.1007/s11926-016-0574-z

PMCID: PMC5453179

PMID: 27032788

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Abstract

The protein product of the progressive ankylosis gene, known as ANK, is a 492-amino acid multi-pass transmembrane protein. This protein is critical for the regulation of pyrophosphate, and gain of function ANK mutations is associated with calcium pyrophosphate deposition disease. Much about the structure, function, and regulation of ANK remain unstudied. This review of the current literature examines recent contributions to our understanding of ANK. We focus on new work on the function, binding partners, and regulators of ANK. A more complete understanding of this important protein may help to identify future therapeutic targets for the treatment of calcium pyrophosphate deposition disease.

Humans

Phosphate Transport Proteins - metabolism

Chondrocalcinosis - genetics

Protein Conformation

Chondrocalcinosis - metabolism

Mutation

Phosphate Transport Proteins - genetics

Details

Title: Subtitle: The Role of ANK in Calcium Pyrophosphate Deposition Disease
Creators: Elizabeth Mitton-Fitzgerald - The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA
Claudia M Gohr - The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA. cgohr@mcw.edu
Brittany Bettendorf - The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA
Ann K Rosenthal - The Division of Rheumatology, Department of Medicine, Medical College of Wisconsin and the Zablocki VA Medical Center, Milwaukee, WI, 53295-1000, USA
Resource Type: Journal article
Publication Details: Current rheumatology reports, Vol.18(5), pp.25-6
DOI: 10.1007/s11926-016-0574-z
PMID: 27032788
PMCID: PMC5453179
NLM abbreviation: Curr Rheumatol Rep
ISSN: 1523-3774
eISSN: 1534-6307
Grant note: I01 CX001143 / CSRD VA
Language: English
Date published: 05/2016
Academic Unit: Immunology; Internal Medicine
Record Identifier: 9984094603402771

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