The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period

Ana Nevarez Gilbert; Adrianne Rahde Bischoff; Kyle Merrill

doi:10.1155/crin/1431773

$The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period$

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The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period

Ana Nevarez Gilbert, Adrianne Rahde Bischoff and Kyle Merrill

Case reports in nephrology, Vol.2025(1), 1431773

01/2025

DOI: 10.1155/crin/1431773

PMCID: PMC11957858

PMID: 40165835

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Abstract

Autosomal recessive polycystic kidney disease (ARPKD) is a form of hereditary cystic disease with a highly variable phenotypic expression that ultimately leads to chronic kidney disease. Severe cases may warrant surgical intervention with unilateral or bilateral nephrectomy to alleviate thoracic and abdominal compression from massive nephromegaly. Hypotension has been identified as a potential complication following nephrectomy in pediatric patients. We present the case of an infant with end‐stage kidney disease secondary to ARPKD who developed refractory hypotension following elective bilateral nephrectomies. We describe the use of angiotensin‐II infusion with a significant increase in mean arterial blood pressure and successful reduction in other inotropic and vasopressor support. This case suggests that angiotensin‐II may represent another valuable therapeutic agent in the treatment of refractory hypotension in anephric infants.

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Title: Subtitle: The Role of Angiotensin‐II Infusion in an Infant With Autosomal Recessive Polycystic Kidney Disease Postbilateral Nephrectomies and Refractory Hypotension in the Neonatal Period
Creators: Ana Nevarez Gilbert - University of Iowa
Adrianne Rahde Bischoff - University of Iowa
Kyle Merrill - University of Iowa
Resource Type: Journal article
Publication Details: Case reports in nephrology, Vol.2025(1), 1431773
DOI: 10.1155/crin/1431773
PMID: 40165835
PMCID: PMC11957858
NLM abbreviation: Case Rep Nephrol
ISSN: 2090-6641
eISSN: 2090-665X
Publisher: Wiley
Language: English
Date published: 01/2025
Academic Unit: Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Neonatology
Record Identifier: 9984802509702771

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