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The Role of Cardiac Magnetic Resonance Imaging in the Evaluation of Malignant Ventricular Arrhythmias in Brugada Syndrome
Journal article   Open access   Peer reviewed

The Role of Cardiac Magnetic Resonance Imaging in the Evaluation of Malignant Ventricular Arrhythmias in Brugada Syndrome

Hunter Frederiksen, Sruti Prathivadhi-Bhayankaram, Barry London and Mahi L. Ashwath
HeartRhythm case reports, Vol.10(1), pp.26-28
01/2024
DOI: 10.1016/j.hrcr.2023.10.014
PMCID: PMC10801090
PMID: 38264111
url
https://doi.org/10.1016/j.hrcr.2023.10.014View
Published (Version of record) Open Access

Abstract

Introduction Brugada syndrome is a genetic disorder associated with an increased risk of sudden cardiac death related to ventricular arrhythmia.1, 2, 3 Initial studies reported rates of syncope or sudden cardiac death ranging from 17% to 42%. Although typically considered channelopathy, subtle structural changes have been reported in this disease's histopathology and magnetic resonance imaging. This includes fibrosis, fatty infiltration, and inflammatory infiltrates with collagen deposition.2 We present a case of a young patient with a known history of Brugada syndrome from an SCN5A mutation who suffered a cardiac arrest and arrhythmias with exercise and was found to have a non-ischemic cardiomyopathy. The case discusses explicitly the pathophysiology and diagnosis of Brugada syndrome, recommended care and management in patients diagnosed with Brugada syndrome, and the role of cardiac magnetic resonance imaging (cMRI) in these patients.
 Brugada syndrome cardiac magnetic resonance imaging myocardial fibrosis sudden cardiac death ventricular arrhythmia

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