The Role of Complement in Kidney Disease: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Marina Vivarelli; Jonathan Barratt; Laurence H. Beck; Fadi Fakhouri; Daniel P. Gale; Elena Goicoechea de Jorge; Marta Mosca; Marina Noris; Matthew C. Pickering; Katalin Susztak; Joshua M. Thurman; Michael Cheung; Jennifer M. King; Michel Jadoul; Wolfgang C. Winkelmayer; Richard J.H. Smith; Federico Alberici; Luca Antonucci; Tadej Avcin; Arvind Bagga; Ingeborg M. Bajema; Miquel Blasco; Sophie Chauvet; H. Terence Cook; Paolo Cravedi; Marie-Agnès Dragon-Durey; Lauren Fischer; Agnes B. Fogo; Ashley Frazer-Abel; Véronique Frémeaux-Bacchi; Nina Görlich; Mark Haas; Alister Humphreys; Vivekanand Jha; Arenn Jauhal; David Kavanagh; Andreas Kronbichler; Richard A. Lafayette; Lynne D. Lanning; Mathieu Lemaire; Moglie Le Quintrec; Christoph Licht; Adrian Liew; Steve McAdoo; Nicholas R. Medjeral-Thomas; Pier Luigi Meroni; Johann Morelle; Carla M. Nester; Manuel Praga; Raja Ramachandran; Heather N. Reich; Giuseppe Remuzzi; Santiago Rodriguez de Cordoba; Gary Robinson; Pierre Ronco; Peter Rossing; David J. Salant; Sanjeev Sethi; Marianne Silkjaer; Wen-chao Song; Fabrizio Spoleti; Ronald P. Taylor; Nicole C.A. J. van de Kar; Cees van Kooten; Len Woodward; Yuzhou Zhang; Peter F. Zipfel; Marco Zuccato; Kidney Disease: Improving Global Outcomes (KDIGO) ConferenceParticipants

doi:10.1016/j.kint.2024.05.015

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The Role of Complement in Kidney Disease: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

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The Role of Complement in Kidney Disease: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Marina Vivarelli, Jonathan Barratt, Laurence H. Beck, Fadi Fakhouri, Daniel P. Gale, Elena Goicoechea de Jorge, Marta Mosca, Marina Noris, Matthew C. Pickering, Katalin Susztak, …

Kidney international, Vol.106(3), pp.369-391

09/2024

DOI: 10.1016/j.kint.2024.05.015

PMID: 38844295

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Abstract

Uncontrolled complement activation can cause or contribute to glomerular injury in multiple kidney diseases. While complement activation plays a causal role in atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G), over the past decade a rapidly accumulating body of evidence has shown a role for complement activation in multiple other kidney diseases, including diabetic nephropathy and several glomerulonephritides. The number of available complement inhibitor therapies has also increased during the same period. In 2022 KDIGO convened a Controversies Conference, The Role of Complement in Kidney Disease, to address the expanding role of complement dysregulation in the pathophysiology, diagnosis, and management of various glomerular diseases, diabetic nephropathy, and other forms of HUS. Conference participants reviewed the evidence for complement playing a primary causal or secondary role in progression for several disease states and considered how evidence of complement involvement might inform management. Participating patients with various complement-mediated diseases and caregivers described concerns related to life planning, implications surrounding genetic testing, and the need for inclusive implementation of effective novel therapies into clinical practice. The value of biomarkers in monitoring disease course and the role of the glomerular microenvironment in complement response were examined, and key gaps in knowledge and research priorities were identified.

complement inhibitor

complement-mediated injury

glomerular injury

Details

Title: Subtitle: The Role of Complement in Kidney Disease: Conclusions From a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference
Creators: Marina Vivarelli - Bambino Gesù Children's Hospital
Jonathan Barratt - University of Leicester
Laurence H. Beck - Boston University
Fadi Fakhouri - Inserm
Daniel P. Gale - University College London
Elena Goicoechea de Jorge - Universidad Complutense de Madrid
Marta Mosca - University of Pisa
Marina Noris - Mario Negri Institute for Pharmacological Research
Matthew C. Pickering - Hammersmith Hospital
Katalin Susztak - Albert Einstein College of Medicine
Joshua M. Thurman - University of Colorado Anschutz Medical Campus
Michael Cheung - KDIGO, Brussels, Belgium
Jennifer M. King - KDIGO, Brussels, Belgium
Michel Jadoul - Cliniques Universitaires Saint-Luc
Wolfgang C. Winkelmayer - Baylor College of Medicine
Richard J.H. Smith - University of Iowa
Federico Alberici
Luca Antonucci
Tadej Avcin
Arvind Bagga
Ingeborg M. Bajema
Miquel Blasco
Sophie Chauvet
H. Terence Cook
Paolo Cravedi
Marie-Agnès Dragon-Durey
Lauren Fischer - Boston University
Agnes B. Fogo
Ashley Frazer-Abel
Véronique Frémeaux-Bacchi
Nina Görlich
Mark Haas
Alister Humphreys
Vivekanand Jha
Arenn Jauhal
David Kavanagh
Andreas Kronbichler
Richard A. Lafayette - University of Iowa
Lynne D. Lanning
Mathieu Lemaire
Moglie Le Quintrec
Christoph Licht
Adrian Liew
Steve McAdoo
Nicholas R. Medjeral-Thomas
Pier Luigi Meroni
Johann Morelle
Carla M. Nester
Manuel Praga
Raja Ramachandran
Heather N. Reich
Giuseppe Remuzzi
Santiago Rodriguez de Cordoba
Gary Robinson
Pierre Ronco
Peter Rossing
David J. Salant
Sanjeev Sethi
Marianne Silkjaer
Wen-chao Song
Fabrizio Spoleti
Ronald P. Taylor
Nicole C.A. J. van de Kar
Cees van Kooten
Len Woodward - Universidad Complutense de Madrid
Yuzhou Zhang
Peter F. Zipfel
Marco Zuccato
Kidney Disease: Improving Global Outcomes (KDIGO) ConferenceParticipants
Resource Type: Journal article
Publication Details: Kidney international, Vol.106(3), pp.369-391
DOI: 10.1016/j.kint.2024.05.015
PMID: 38844295
NLM abbreviation: Kidney Int
ISSN: 0085-2538
eISSN: 1523-1755
Publisher: Elsevier Inc
Grant note: The conference was sponsored by Kidney Disease: Improving Global Outcomes (KDIGO) and was supported in part by unrestricted educational grants from Alexion, Alnylam Pharmaceuticals, Apellis, BioCryst, Calliditas Therapeutics, ChemoCentryx, Chinook Therapeutics, CSL Vifor, Novartis, Omeros, Otsuka, Roche, Sanofi, and Visterra. The authors thank Debbie Maizels for assistance with illustrations.
Language: English
Electronic publication date: 06/04/2024
Date published: 09/2024
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Molecular Physiology and Biophysics; Anatomy and Cell Biology; Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Otolaryngology; Internal Medicine
Record Identifier: 9984642759702771

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