The Role of Environmental Factors in the Etiology of Nonsyndromic Orofacial Clefts

Mekonen Eshete; Azeez Butali; Fikre Abate; Taye Hailu; Abiye Hailu; Shiferaw Degu; Yohannes Demissie; Paul E Gravem; Miliard Derbew; Peter Mossey; Tamara Bush; Wakgari Deressa

doi:10.1097/SCS.0000000000005924

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The Role of Environmental Factors in the Etiology of Nonsyndromic Orofacial Clefts

Journal article

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The Role of Environmental Factors in the Etiology of Nonsyndromic Orofacial Clefts

Mekonen Eshete, Azeez Butali, Fikre Abate, Taye Hailu, Abiye Hailu, Shiferaw Degu, Yohannes Demissie, Paul E Gravem, Miliard Derbew, Peter Mossey, …

The Journal of craniofacial surgery, Vol.31(1), pp.113-116

01/2020

DOI: 10.1097/SCS.0000000000005924

PMID: 31821209

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https://discovery.dundee.ac.uk/en/publications/8f136c56-606f-4b74-98dd-2d6a0f1fe0beView

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Abstract

Nonsyndromic orofacial clefts (NSOFCs) represent the most common congenital anomalies in the head and neck region. Multiple factors contribute to the occurrence of this anomaly. The etiology of NSOFCs in the Ethiopian population has not been investigated prior to this study. To assess the role of maternal environmental factors in the occurrence of NSOFCs in the Ethiopian Population. The authors used unmatched case control study design and evaluated the role of environmental factors to the occurrence of NSOFCs in the Ethiopian population. The participants were recruited from the same institution (Yekatit 12 Hospital Medical College). The authors studied 760 mothers (359 mothers of children born with NSOFCs and 401 mothers of children born without any congenital anomalies). Univariate and multivariate logistic regression analyses were used to calculate relative risk by odds ratio and 95% confidence interval. Mothers who gave history of bronchial asthma and mothers who were admitted for threatened abortion had a higher risk of delivering a child with NSOFCS P value=0.013; AOR=0.194, 95% CI [0.053-0.712], P value <0.001; AOR= 0.179, 95% CI [0.091-0.352] respectively. Higher number of children with NSOFCs were born to mothers who were exposed to diagnostic X-ray investigation during early pregnancy than those who were not exposed P value 0.048; AOR=0.375, 95% CI [0.142-0.990]. Maternal exposure to diagnostic x-ray, maternal chronic illness like bronchial asthma and threatened abortion were found to be associated with the occurrence of NSOFCS in the studied population.

Brain - abnormalities

Case-Control Studies

Child, Preschool

Cleft Lip - etiology

Cleft Palate - etiology

Female

Humans

Infant

Maternal Exposure

Mothers

Pregnancy

Risk Factors

Details

Title: Subtitle: The Role of Environmental Factors in the Etiology of Nonsyndromic Orofacial Clefts
Creators: Mekonen Eshete - Addis Ababa University
Azeez Butali - University of Iowa
Fikre Abate - KIST Medical College
Taye Hailu - KIST Medical College
Abiye Hailu - College of Health Sciences, Bahrain
Shiferaw Degu - Addis Ababa University
Yohannes Demissie - College of Health Sciences, Bahrain
Paul E Gravem - Haukeland University Hospital
Miliard Derbew - Addis Ababa University
Peter Mossey - University of Dundee
Tamara Bush - University of Iowa
Wakgari Deressa - Addis Ababa University
Resource Type: Journal article
Publication Details: The Journal of craniofacial surgery, Vol.31(1), pp.113-116
DOI: 10.1097/SCS.0000000000005924
PMID: 31821209
NLM abbreviation: J Craniofac Surg
ISSN: 1536-3732
eISSN: 1536-3732
Language: English
Date published: 01/2020
Academic Unit: Oral Pathology, Radiology and Medicine; Stead Family Department of Pediatrics; Craniofacial Anomalies Research Center; Dental Research
Record Identifier: 9984353840502771

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