Journal article
The Role of GABRA2 in Risk for Conduct Disorder and Alcohol and Drug Dependence across Developmental Stages
Behavior genetics, Vol.36(4), pp.577-590
07/2006
DOI: 10.1007/s10519-005-9041-8
PMID: 16557364
Abstract
We use findings from the behavior genetics literature about how genetic factors (latently) influence alcohol dependence and related disorders to develop and test hypotheses about the risk associated with a specific gene, GABRA2, across different developmental stages. This gene has previously been associated with adult alcohol dependence in the Collaborative Study of the Genetics of Alcoholism (COGA) sample [Edenberg, H. J., Dick, D. M., Xuei, X., Tian, H., Almasy, L., Bauer, L. O., Crowe, R., Goate, A., Hesselbrock, V., Jones, K. A., Kwon, J., Li, T. K., Nurnberger Jr., J. I., O’Connor, S. J., Reich, T., Rice, J., Schuckit, M., Porjesz, B., Foroud, T., and Begleiter, H. (2004). Am. J. Hum. Genet. 74:705–714] and other studies [Covault, J., Gelernter, J., Hesselbrock, V., Nellissery, M., and Kranzler, H. R. (2004). Am. J. Med. Genet. B Neuropsychiatr. Genet. 129B:104–109; Lappalainen, J., Krupitsky, E., Remizov, M., Pchelina, S., Taraskina, A., Zvartau, E., Somberg, L. K., Covault, J., Kranzler, H. R., Krystal, J., and Gelernter, J. (2005). Alcohol. Clin. Exp. Res. 29:493–498]. In a sample of children and adolescents ascertained as part of the COGA project, we find that GABRA2 is significantly associated with childhood conduct disorder symptoms, but not with childhood alcohol dependence symptoms. A consistent elevation in risk for alcohol dependence associated with GABRA2 is not evident until the mid-20s and then remains throughout adulthood. GABRA2 is also associated with other drug dependence in our sample, both in adolescence and adulthood.
Details
- Title: Subtitle
- The Role of GABRA2 in Risk for Conduct Disorder and Alcohol and Drug Dependence across Developmental Stages
- Creators
- Danielle Dick - WUSM Psychiatry Box 8134 660 South Euclid St. Louis MO 63110 USALaura Bierut - Department of Psychiatry and Psychology Washington University School of Medicine St. Louis MO USAAnthony Hinrichs - Department of Psychiatry and Psychology Washington University School of Medicine St. Louis MO USALouis Fox - Department of Psychiatry and Psychology Washington University School of Medicine St. Louis MO USAKathleen Bucholz - Department of Psychiatry and Psychology Washington University School of Medicine St. Louis MO USAJohn Kramer - University of Iowa School of Medicine Iowa City IA USASamuel Kuperman - University of Iowa School of Medicine Iowa City IA USAVictor Hesselbrock - University of Connecticut School of Medicine Farmington CT USAMarc Schuckit - University of California at San Diego School of Medicine La Jolla CA USALaura Almasy - Southwest Foundation San Antonio TX USAJay Tischfield - Rutgers University Piscataway NJ USABernice Porjesz - SUNY Health Science Center at Brooklyn Brooklyn NY USAHenri Begleiter - SUNY Health Science Center at Brooklyn Brooklyn NY USAJohn Nurnberger Jr - Indiana University School of Medicine Indianapolis IN USAXiaoling Xuei - Indiana University School of Medicine Indianapolis IN USAHoward Edenberg - Indiana University School of Medicine Indianapolis IN USATatiana Foroud - Indiana University School of Medicine Indianapolis IN USA
- Resource Type
- Journal article
- Publication Details
- Behavior genetics, Vol.36(4), pp.577-590
- Publisher
- Kluwer Academic Publishers-Plenum Publishers; New York
- DOI
- 10.1007/s10519-005-9041-8
- PMID
- 16557364
- ISSN
- 0001-8244
- eISSN
- 1573-3297
- Language
- English
- Date published
- 07/2006
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984004184502771
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