Journal article
The Role of GABRA2 on risk for Alcohol, Nicotine and Cannabis Dependence in the Iowa Adoption Studies
Psychiatric genetics, Vol.19(2), pp.91-98
04/2009
DOI: 10.1097/YPG.0b013e3283208026
PMCID: PMC3643116
PMID: 19672139
Abstract
A number of studies have demonstrated that genetic variation at
GABRA2
alters vulnerability to alcohol dependence. However, the exact identity of the causal variant(s), the relationship of these variants to other forms of substance use and behavioral illness is uncertain. Therefore, we genotyped 516 subjects from the Iowa Adoption Studies, a large longitudinal case and control adoption study of substance use, at 39 single nucleotide polymorphisms encompassing the
GABRA2
locus and analyzed them with respect to their lifetime history of three common forms of substance use (alcohol (AD), nicotine (ND) and cannabis dependence (CD)), major depressive disorder (MDD) and antisocial personality disorder (ASPD) and relevant exposure variables. Using regression analysis, we found substantial evidence that both
GABRA2
genotype and haplotype are significantly related to vulnerability to AD, ND and CD with the strongest relationships noted with respect to ND. Consistent with prior studies suggesting exposure is an important step in the development of substance use, we found the inclusion of substance exposure data in to our analytic models markedly increased the strength of the genetic associations of
GABRA2
haplotype with substance use. Finally, we report that the genetic effects were markedly more pronounced in females than in males. We conclude that genetic variation at or near the
GABRA2
locus significantly effects vulnerability not only to AD, but to other forms of substance use including ND and CD, and that the effects may be sex dependent.
Details
- Title: Subtitle
- The Role of GABRA2 on risk for Alcohol, Nicotine and Cannabis Dependence in the Iowa Adoption Studies
- Creators
- Robert A Philibert - University of IowaTracy D Gunter - University of IowaSteven R. H Beach - University of Georgia, Athens GAGene H Brody - University of Georgia, Athens GANancy Hollenbeck - University of IowaAllan Andersen - Georgetown UniversityWilliam Adams - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Psychiatric genetics, Vol.19(2), pp.91-98
- DOI
- 10.1097/YPG.0b013e3283208026
- PMID
- 19672139
- PMCID
- PMC3643116
- NLM abbreviation
- Psychiatr Genet
- ISSN
- 0955-8829
- eISSN
- 1473-5873
- Grant note
- R01 AA012768 || AA / National Institute on Alcohol Abuse and Alcoholism : NIAAA R01 DA019230 || DA / National Institute on Drug Abuse : NIDA R01 HD030588 || HD / National Institute of Child Health & Human Development : NICHD R01 DA021736 || DA / National Institute on Drug Abuse : NIDA
- Language
- English
- Date published
- 04/2009
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003461902771
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