Journal article
The Role of Home-Based Exercise in Maintaining Skeletal Muscle During Preoperative Pancreatic Cancer Treatment
Integrative cancer therapies, Vol.20, pp.1534735420986615-1534735420986615
04/01/2021
DOI: 10.1177/1534735420986615
PMCID: PMC8056559
PMID: 33870744
Abstract
Loss of skeletal muscle and inferior muscle quality are associated with poor prognosis in patients undergoing preoperative treatment for pancreatic cancer, so maintaining skeletal muscle health before surgery may help accelerate patients' functional recovery and improve their quality of life following surgery. While exercise helps maintain or increase skeletal muscle in individuals undergoing cancer treatment, its efficacy during pancreatic cancer treatment is unclear. Accordingly, in this study we compared changes in skeletal muscle quantity (skeletal muscle index [SMI]) and quality (skeletal muscle density [SMD]) during preoperative pancreatic cancer treatment in participants in a home-based exercise program (EP) and a historical cohort of patients who received the usual care (UC) with no formal exercise programming. Recommendations for the EP cohort included both aerobic and resistance exercise. We assessed changes in SMI and SMD using computed tomography scans administered at treatment planning (T0, prior to EP enrollment) and preoperative restaging (T1) for 33 EP and 64 UC patients and compared changes between groups. The UC patients had statistically significant SMI decreases from T0 to T1 (-1.4 +/- 3.8 cm(2)/m(2); p = .005), while the EP patients did not (0.2 +/- 3.2 cm(2)/m(2); p = .7). The SMI loss was significantly worse for the UC than for the EP patients (p = .03). Neither group demonstrated statistically significant changes in SMD from T0 to T1, nor did the groups differ in the amount of change in SMD. An adjusted linear regression model demonstrated that EP participation was significantly associated with better SMI maintenance (p = .02). These results suggest that participation in a home-based EP during preoperative treatment may help improve skeletal muscle health and clinical and quality of life outcomes for pancreatic cancer survivors.
Details
- Title: Subtitle
- The Role of Home-Based Exercise in Maintaining Skeletal Muscle During Preoperative Pancreatic Cancer Treatment
- Creators
- Nathan H. Parker - The University of Texas MD Anderson Cancer CenterJessica Gorzelitz - University of Wisconsin–MadisonAn Ngo-Huang - The University of Texas MD Anderson Cancer CenterBette J. Caan - Kaiser PermanenteLaura Prakash - The University of Texas MD Anderson Cancer CenterNaveen Garg - The University of Texas MD Anderson Cancer CenterMaria Q. B. Petzel - The University of Texas MD Anderson Cancer CenterKeri Schadler - The University of Texas MD Anderson Cancer CenterKaren Basen-Engquist - The University of Texas MD Anderson Cancer CenterMatthew H. G. Katz - The University of Texas MD Anderson Cancer Center
- Resource Type
- Journal article
- Publication Details
- Integrative cancer therapies, Vol.20, pp.1534735420986615-1534735420986615
- DOI
- 10.1177/1534735420986615
- PMID
- 33870744
- PMCID
- PMC8056559
- NLM abbreviation
- Integr Cancer Ther
- ISSN
- 1534-7354
- eISSN
- 1552-695X
- Publisher
- Sage
- Number of pages
- 10
- Grant note
- P30CA016672; 5R21CA218732-02 / NIH/NCI; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Cancer Institute (NCI) University of Texas MD Anderson Cancer Center Duncan Family Institute for Cancer Prevention and Risk Assessment RP170259 / Cancer Prevention and Research Institute of Texas Training Grant/MD Anderson Cancer Prevention Research Training Program R25CA203650 / Transdisciplinary Research on Energetics and Cancer (TREC) Training Workshop MD Anderson Center for Energy Balance in Cancer Prevention and Survivorship, Duncan Family Institute for Cancer Prevention and Risk Assessment Knox Family Foundation
- Language
- English
- Date published
- 04/01/2021
- Academic Unit
- Health, Sport, and Human Physiology
- Record Identifier
- 9984294923802771
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