Journal article
The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses
Advances in experimental medicine and biology, Vol.850, pp.31-41
2015
DOI: 10.1007/978-3-319-15774-0_3
PMID: 26324344
Abstract
Antigen-specific CD8 T cells provide an important protective role in response to infection by viruses, intracellular bacteria, and parasites. Pathogen-specific CD8 T cells render this protection by undergoing robust expansion in numbers while gaining the ability to produce cytokines and cytolytic machinery. Creating optimal CD8 T cell responses to infection can be critical for raising sufficient armament to provide protection against invading intracellular pathogens. Although CD8 T cells have protective value, many vaccine strategies tend to focus on creating productive B cell antibody responses to promote immunological protection. Even though antibody responses can be highly protective, coupling optimal CD8 T cell responses with suboptimal B cell responses could provide higher orders of protection than either one on their own. Therefore, a deeper understanding of the pathways that ultimately guide the magnitude of CD8 T cell responses is required to explore this potential therapeutic benefit. The following chapter highlights our current understanding of how inflammatory cytokines regulate the magnitude of CD8 T cell responses.
Details
- Title: Subtitle
- The Role of Il-12 and Type I Interferon in Governing the Magnitude of CD8 T Cell Responses
- Creators
- Gabriel R Starbeck-Miller - Interdisciplinary Graduate Program in Immunology, University of Iowa, 52242, Iowa City, IA, USA, gabriel.starbeck.miller@gmail.comJohn T Harty
- Resource Type
- Journal article
- Publication Details
- Advances in experimental medicine and biology, Vol.850, pp.31-41
- Publisher
- United States
- DOI
- 10.1007/978-3-319-15774-0_3
- PMID
- 26324344
- eISBN
- 9783319157740; 3319157744
- ISSN
- 0065-2598
- eISSN
- 2214-8019
- Language
- English
- Date published
- 2015
- Academic Unit
- Pathology
- Record Identifier
- 9984046803002771
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