Journal article
The Role of Iron in the Susceptibility of Neonatal Mice to Escherichia coli K1 Sepsis
The Journal of infectious diseases, Vol.220(7), pp.1219-1229
10/01/2019
DOI: 10.1093/infdis/jiz282
PMCID: PMC7325330
PMID: 31136646
Abstract
Sepsis from Escherichia coli expressing the K1 antigen is a leading cause of death in neonates. In a murine model, E. coli K1 grew rapidly in the peritoneal cavity of neonatal mice, causing fatal disease. In contrast, adult mice cleared the infection. Neonatal mice mounted a rapid and equivalent antimicrobial immune response compared to adult mice. Interestingly, peritoneal fluid from neonatal mice contained significantly more total iron than that of adult mice, which was sufficient to support enhanced E. coli growth. Transient iron overload in adult mice infected with E. coli resulted in 100% mortality. Maternal diet-induced mild iron deficiency decreased offspring peritoneal iron, decreased bacterial growth, and conferred protection against sepsis. Taken together, neonatal susceptibility to E. coli K1 sepsis is enhanced by a localized excess of peritoneal iron that allows for unchecked bacterial growth. Targeting this excess iron may provide a new therapeutic target in human patients.
Details
- Title: Subtitle
- The Role of Iron in the Susceptibility of Neonatal Mice to Escherichia coli K1 Sepsis
- Creators
- Kathryn R. Michels - University of Michigan–Ann ArborNathalie J. Lambrecht - University of Michigan–Ann ArborWilliam F Carson IV - University of Michigan–Ann ArborMatthew A. Schaller - University of Michigan–Ann ArborNicholas W. Lukacs - University of Michigan–Ann ArborJennifer R. Bermick - Michigan Medicine
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.220(7), pp.1219-1229
- Publisher
- Oxford Univ Press
- DOI
- 10.1093/infdis/jiz282
- PMID
- 31136646
- PMCID
- PMC7325330
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Number of pages
- 11
- Grant note
- 5K12HD028820-22 / National Institutes of Health Child Health Research Center UL1TR000433 / University of Michigan Institute for Clinical and Health Research Department of Pediatrics at the University of Michigan Korneffel family T32HL007517 / NATIONAL HEART, LUNG, AND BLOOD INSTITUTE; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Heart Lung & Blood Institute (NHLBI)
- Language
- English
- Date published
- 10/01/2019
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology
- Record Identifier
- 9984354155502771
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