Journal article
The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
International journal of molecular sciences, Vol.23(7837), p.7837
07/01/2022
DOI: 10.3390/ijms23147837
PMCID: PMC9320310
PMID: 35887184
Abstract
Platelet-derived extracellular vesicles (PEVs) play important roles in hemostasis and thrombosis. There are three major types of PEVs described based on their size and characteristics, but newer types may continue to emerge owing to the ongoing improvement in the methodologies and terms used to define various types of EVs. As the literature on EVs is growing, there are continuing attempts to standardize protocols for EV isolation and reach consensus in the field. This review provides information on mechanisms of PEV production, characteristics, cellular interaction, and their pathological role, especially in autoimmune and infectious diseases. We also highlight the mechanisms through which PEVs can activate parent cells in a feedback loop.
Details
- Title: Subtitle
- The Role of Platelet-Derived Extracellular Vesicles in Immune-Mediated Thrombosis
- Creators
- Alicia S. Eustes - University of IowaSanjana Dayal - University of Iowa
- Resource Type
- Journal article
- Publication Details
- International journal of molecular sciences, Vol.23(7837), p.7837
- DOI
- 10.3390/ijms23147837
- PMID
- 35887184
- PMCID
- PMC9320310
- NLM abbreviation
- Int J Mol Sci
- ISSN
- 1661-6596
- eISSN
- 1422-0067
- Publisher
- MDPI AG
- Grant note
- DOI: 10.13039/100000002, name: National Institutes of Health, award: R01AI162778; name: Office of Research and Development and Department of Veterans Affairs, award: I01CX001932
- Language
- English
- Date published
- 07/01/2022
- Academic Unit
- Hematology, Oncology, and Blood & Marrow Transplantation; Iowa Neuroscience Institute; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984276446402771
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