Journal article
The Role of Secretory Immunity in Hepatitis A Virus Infection
The Journal of infectious diseases, Vol.163(1), pp.7-11
01/1991
DOI: 10.1093/infdis/163.1.7
PMID: 1845810
Abstract
Because the role of intestinal immunity remains uncertain in hepatitis A, samples of feces and saliva from infected primates and humans were tested for virus neutralizing activity. Only two of eight owl monkeys infected by the intragastric route developed neutralizing antibody detectable in extracts of feces collected up to 88 days after viral challenge, although serum neutralizing antibody was present in all monkeys by day 33. Similarly, neutralizing antibody was detected in fecal extracts from none of three experimentally infected human volunteers and only 1 of 15 naturally infected humans. The single positive human specimen contained occult blood. Only 2 of 19 saliva samples from naturally infected humans had significant viral neutralizing activity. In contrast, neutralizing antibody to type 2 polio virus was present in most human fecal or saliva specimens tested. These data suggest that intestinal immunity does not playa significant role in protection against hepatitis A.
Details
- Title: Subtitle
- The Role of Secretory Immunity in Hepatitis A Virus Infection
- Creators
- Jack T Stapleton - Division of Infectious Diseases, Departments of Internal Medicine, VA Medical Center and University of Iowa, Iowa City, Fort Detrick, Frederick, Maryland, Washington, DC, Chapel HillDavid K Lange - Division of Infectious Diseases, Departments of Internal Medicine, VA Medical Center and University of Iowa, Iowa City, Fort Detrick, Frederick, Maryland, Washington, DC, Chapel HillJames W LeDuc - Division of Infectious Diseases, Departments of Internal Medicine, VA Medical Center and University of Iowa, Iowa City, Fort Detrick, Frederick, Maryland, Washington, DC, Chapel HillLeonard N Binn - Division of Infectious Diseases, Departments of Internal Medicine, VA Medical Center and University of Iowa, Iowa City, Fort Detrick, Frederick, Maryland, Washington, DC, Chapel HillRobert W Jansen - Division of Infectious Diseases, Departments of Internal Medicine, VA Medical Center and University of Iowa, Iowa City, Fort Detrick, Frederick, Maryland, Washington, DC, Chapel HillStanley M Lemon - Division of Infectious Diseases, Departments of Internal Medicine, VA Medical Center and University of Iowa, Iowa City, Fort Detrick, Frederick, Maryland, Washington, DC, Chapel Hill
- Resource Type
- Journal article
- Publication Details
- The Journal of infectious diseases, Vol.163(1), pp.7-11
- Publisher
- The University of Chicago Press
- DOI
- 10.1093/infdis/163.1.7
- PMID
- 1845810
- ISSN
- 0022-1899
- eISSN
- 1537-6613
- Language
- English
- Date published
- 01/1991
- Academic Unit
- Microbiology and Immunology; Infectious Diseases; Internal Medicine
- Record Identifier
- 9984094557802771
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