Journal article
The Role of Synaptic Cell Adhesion Molecules and Associated Scaffolding Proteins in Social Affiliative Behaviors
Biological psychiatry (1969), Vol.88(6), pp.442-451
09/15/2020
DOI: 10.1016/j.biopsych.2020.02.012
PMID: 32305215
Abstract
Social affiliative behaviors—engagement in positive (i.e., nonaggressive) social approach and reciprocal social interactions with a conspecific—comprise a construct within the National Institute of Mental Health Research Domain Criteria Social Processes Domain. These behaviors are disrupted in multiple human neurodevelopmental and neuropsychiatric disorders, such as autism, schizophrenia, social phobia, and others. Human genetic studies have strongly implicated synaptic cell adhesion molecules (sCAMs) in several such disorders that involve marked reductions, or other dysregulations, of social affiliative behaviors. Here, we review the literature on the role of sCAMs in social affiliative behaviors. We integrate findings pertaining to synapse structure and morphology, neurotransmission, postsynaptic signaling pathways, and neural circuitry to propose a multilevel model that addresses the impact of a diverse group of sCAMs, including neurexins, neuroligins, protocadherins, immunoglobulin superfamily proteins, and leucine-rich repeat proteins, as well as their associated scaffolding proteins, including SHANKs and others, on social affiliative behaviors. This review finds that the disruption of sCAMs often manifests in changes in social affiliative behaviors, likely through alterations in synaptic maturity, pruning, and specificity, leading to excitation/inhibition imbalance in several key regions, namely the medial prefrontal cortex, basolateral amygdala, hippocampus, anterior cingulate cortex, and ventral tegmental area. Unraveling the complex network of interacting sCAMs in glutamatergic synapses will be an important strategy for elucidating the mechanisms of social affiliative behaviors and the alteration of these behaviors in many neuropsychiatric and neurodevelopmental disorders.
Details
- Title: Subtitle
- The Role of Synaptic Cell Adhesion Molecules and Associated Scaffolding Proteins in Social Affiliative Behaviors
- Creators
- Sara C Taylor - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaSarah L Ferri - Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IowaMahip Grewal - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaZoe Smernoff - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaMaja Bucan - Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PennsylvaniaJoshua A Weiner - Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IowaTed Abel - Iowa Neuroscience Institute, Roy J. and Lucille A. Carver College of Medicine, University of Iowa, Iowa City, IowaEdward S Brodkin - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania
- Resource Type
- Journal article
- Publication Details
- Biological psychiatry (1969), Vol.88(6), pp.442-451
- DOI
- 10.1016/j.biopsych.2020.02.012
- PMID
- 32305215
- NLM abbreviation
- Biol Psychiatry
- ISSN
- 0006-3223
- eISSN
- 1873-2402
- Publisher
- Elsevier Inc
- Grant note
- DOI: 10.13039/100006399, name: Spectrum; DOI: 10.13039/100004897, name: Pennsylvania Department of Health
- Language
- English
- Date published
- 09/15/2020
- Academic Unit
- Liberal Arts and Science Admin; Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Biology; Developmental and Behavioral Pediatrics; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984070796002771
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