Journal article
The Role of the Thalamus in Schizophrenia
Canadian journal of psychiatry, Vol.42(1), pp.27-33
02/1997
DOI: 10.1177/070674379704200104
PMID: 9040920
Abstract
Background:
Explaining the diversity of symptoms that occur in schizophrenia is a major conceptual challenge. Perhaps the most powerful strategy is to identify a fundamental cognitive process and/or a fundamental neural circuit.
Methods:
Convergent data from our research group in Iowa and from investigators in other centres are summarized.
Results:
The thalamus plays a key role in information processing. A defect in circuitry connecting the thalamus, frontal cortex, and cerebellum could explain a wide range of symptoms. Neuropathology and imaging studies suggest that patients with schizophrenia may have abnormalities in this circuitry.
Conclusion:
The fundamental deficit in schizophrenia may be conceptualized as a “cognitive dysmetria” characterized by impairments in coordinating the perception, encoding, retrieval, and prioritization of experience and information.
Details
- Title: Subtitle
- The Role of the Thalamus in Schizophrenia
- Creators
- Nancy C Andreasen - Andrew H Woods Professor of Psychiatry, Mental Health Clinical Research Center, The University of Iowa College of Medicine and University of Iowa Hospitals and Clinics, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Canadian journal of psychiatry, Vol.42(1), pp.27-33
- DOI
- 10.1177/070674379704200104
- PMID
- 9040920
- ISSN
- 0706-7437
- eISSN
- 1497-0015
- Language
- English
- Date published
- 02/1997
- Academic Unit
- Psychiatry; Iowa Neuroscience Institute
- Record Identifier
- 9984003923702771
Metrics
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