Journal article
The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned
Contemporary clinical trials, Vol.60, pp.14-23
09/2017
DOI: 10.1016/j.cct.2017.06.008
PMCID: PMC5557648
PMID: 28619649
Abstract
Asthma is the most common chronic disease of childhood in the United States, causes significant morbidity, particularly in the inner-city, and accounts for billions of dollars in health care utilization. Home environments are established sources of exposure that exacerbate symptoms and home-based interventions are effective. However, elementary school children spend 7 to 12h a day in school, primarily in one classroom. From the observational School Inner-City Asthma Study we learned that student classroom-specific exposures are associated with worsening asthma symptoms and decline in lung function. We now embark on a randomized, blinded, sham-controlled school environmental intervention trial, built on our extensively established school/community partnerships, to determine the efficacy of a school-based intervention to improve asthma control. This factorial school/classroom based environmental intervention will plan to enroll 300 students with asthma from multiple classrooms in 40 northeastern inner-city elementary schools. Schools will be randomized to receive either integrated pest management versus control and classrooms within these schools to receive either air purifiers or sham control. The primary outcome is asthma symptoms during the school year. This study is an unprecedented opportunity to test whether a community of children can benefit from school or classroom environmental interventions. If effective, this will have great impact as an efficient, cost-effective intervention for inner city children with asthma and may have broad public policy implications.
Details
- Title: Subtitle
- The School Inner-City Asthma Intervention Study: Design, rationale, methods, and lessons learned
- Creators
- Wanda Phipatanakul - Boston Children's Hospital, Division of Allergy and Immunology, Boston, MA, United StatesPetros Koutrakis - Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, United StatesBrent A Coull - Harvard T.H. Chan School of Public Health, Department of Biostatistics, Boston, MA, United StatesChoong-Min Kang - Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, United StatesJack M Wolfson - Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, United StatesStephen T Ferguson - Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, United StatesCarter R Petty - Boston Children's Hospital, Clinical Research Center, Boston, MA, United StatesMihail Samnaliev - Boston Children's Hospital, Clinical Research Center, Boston, MA, United StatesAmparito Cunningham - Boston Children's Hospital, Division of Allergy and Immunology, Boston, MA, United StatesWilliam J Sheehan - Boston Children's Hospital, Division of Allergy and Immunology, Boston, MA, United StatesJonathan M Gaffin - Harvard Medical School, Boston, MA, United StatesSachin N Baxi - Boston Children's Hospital, Division of Allergy and Immunology, Boston, MA, United StatesPeggy S Lai - Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, United StatesPerdita Permaul - Massachusetts General Hospital, Division of Pediatric Allergy and Immunology, Boston, MA, United StatesLiming Liang - Harvard T.H. Chan School of Public Health, Department of Biostatistics, Boston, MA, United StatesPeter S Thorne - University of Iowa, Department of Occupational and Environmental Health, Iowa City, United StatesGary Adamkiewicz - Harvard T.H. Chan School of Public Health, Department of Environmental Health, Boston, MA, United StatesKasey J Brennan - Columbia University School of Public Health, New York, Department of Environmental Health, New York, United StatesAndrea A Baccarelli - Columbia University School of Public Health, New York, Department of Environmental Health, New York, United StatesDiane R Gold - Harvard Medical School, Boston, MA, United States
- Resource Type
- Journal article
- Publication Details
- Contemporary clinical trials, Vol.60, pp.14-23
- DOI
- 10.1016/j.cct.2017.06.008
- PMID
- 28619649
- PMCID
- PMC5557648
- NLM abbreviation
- Contemp Clin Trials
- ISSN
- 1551-7144
- eISSN
- 1559-2030
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 09/2017
- Academic Unit
- Civil and Environmental Engineering; Occupational and Environmental Health
- Record Identifier
- 9983997447702771
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