Journal article
The Score Statistic of the LD-Lod Analysis: Detecting Linkage Adaptive to Linkage Disequilibrium
Human heredity, Vol.52(2), pp.83-98
07/2001
DOI: 10.1159/000053359
PMID: 11474209
Abstract
We study the properties of a modified lod score method for testing linkage that incorporates linkage disequilibrium (LD-lod). By examination of its score statistic, we show that the LD-lod score method adaptively combines two sources of information: (a) the IBD sharing score which is informative for linkage regardless of the existence of LD and (b) the contrast between allele-specific IBD sharing scores which is informative for linkage only in the presence of LD. We also consider the connection between the LD-lod score method and the transmission-disequilibrium test (TDT) for triad data and the mean test for affected sib pair (ASP) data. We show that, for triad data, the recessive LD-lod test is asymptotically equivalent to the TDT; and for ASP data, it is an adaptive combination of the TDT and the ASP mean test. We demonstrate that the LD-lod score method has relatively good statistical efficiency in comparison with the ASP mean test and the TDT for a broad range of LD and the genetic models considered in this report. Therefore, the LD-lod score method is an interesting approach for detecting linkage when the extent of LD is unknown, such as in a genome-wide screen with a dense set of genetic markers.
Details
- Title: Subtitle
- The Score Statistic of the LD-Lod Analysis: Detecting Linkage Adaptive to Linkage Disequilibrium
- Creators
- Jian Huang - University of IowaYanming Jiang
- Resource Type
- Journal article
- Publication Details
- Human heredity, Vol.52(2), pp.83-98
- DOI
- 10.1159/000053359
- PMID
- 11474209
- ISSN
- 0001-5652
- eISSN
- 1423-0062
- Number of pages
- 16
- Language
- English
- Date published
- 07/2001
- Academic Unit
- Statistics and Actuarial Science
- Record Identifier
- 9984257616202771
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