Journal article
The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition
Chest, Vol.156(4), pp.685-695
10/2019
DOI: 10.1016/j.chest.2019.03.041
PMCID: PMC6859248
PMID: 31047955
Abstract
Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown.
We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study with longitudinal follow-up data on exacerbations. Subjects were divided into classic CB+ or classic CB–, using the classic definition. In addition, subjects were divided into SGRQ CB+ or SGRQ CB–. Exacerbation frequency and severe exacerbation frequency were determined in each group. Multivariable linear regressions were performed for exacerbation frequency with either classic CB or SGRQ CB and relevant covariates.
There were 1,434 classic CB+ subjects and 2,290 SGRQ CB+ subjects. The classic CB+ group had a greater exacerbation frequency compared with the classic CB– group (0.69 ± 1.26 vs 0.36 ± 0.90 exacerbations per patient per year; P < .0001) and a greater severe exacerbation frequency (0.26 ± 0.74 vs 0.13 ± 0.46 severe exacerbations per patient per year; P < .0001). There were similar differences between the SGRQ CB+ and SGRQ CB– groups. In multivariable analysis, both SGRQ CB and classic CB were independent predictors of exacerbation frequency, but SGRQ CB had a higher regression coefficient. In addition, SGRQ CB was an independent predictor of severe exacerbation frequency whereas classic CB was not.
The SGRQ CB definition identified more subjects at risk for future exacerbations than the classic CB definition. SGRQ CB was at least a similar if not better predictor of future exacerbations than classic CB.
Details
- Title: Subtitle
- The St. George’s Respiratory Questionnaire Definition of Chronic Bronchitis May Be a Better Predictor of COPD Exacerbations Compared With the Classic Definition
- Creators
- Victor Kim - Temple UniversityHuaqing Zhao - Temple UniversityElizabeth Regan - National Jewish HealthMeiLan K. Han - University of MichiganBarry J. Make - National Jewish HealthJames D. Crapo - National Jewish HealthPaul W. Jones - St George's HospitalJeffrey L. Curtis - VA Ann Arbor Healthcare System, Ann Arbor, MIEdwin K. Silverman - Brigham and Women's HospitalGerard J. Criner - Temple UniversityMegan E. HardinLystra P. HaydenCraig P. HershJacqueline HetmanskiBrian D. HobbsJohn E. HokansonNan LairdChristoph LangeSharon M. LutzMerry-Lynn McDonaldMargaret M. ParkerDandi QiaoStephanie SantoricoEmily S. WanSungho WonJean-Paul CharbonnierHarvey O. CoxsonEric A. HoffmanStephen HumphriesFrancine L. JacobsonPhilip F. JudyElla A. KazerooniAlex KluiberDavid A. LynchJohn D. NewellJames C. RossRaul San Jose EsteparJered SierenBerend C. StoelJuerg TschirrenEdwin Van BeekBram van GinnekenEva van RikxoortCarla G. WilsonGeorge WashkoRobert JensenDouglas EverettJim CrooksCamille MooreMatt StrandJohn HughesGregory KinneyKatherine PratteKendra A. YoungCarlos H. MartinezPerry G. PernicanoNicola HananiaPhilip AlapatMustafa AtikVenkata BandiAladin BoriekKalpatha GuntupalliElizabeth GuyArun NachiappanAmit ParulekarR. Graham BarrJohn AustinBelinda D’SouzaGregory D.N. PearsonAnna RozenshteinByron ThomashowNeil MacIntyreH. Page McAdamsLacey WashingtonCharlene McEvoyHarry RossiterJoseph TashjianWilliam StringerRobert WiseAmir SharafkhanehRobert BrownCharlie LanChristine WendtKaren HortonBrian BellAllison LambertEric L. FlenaughAlessandra AdamiRichard CasaburiGloria WestneyRussell BowlerMatthew BudoffRichard RosielloEugene BerkowitzHans FischerNirupama PutchaDavid PaceJanos PorszaszDavid CiccolellaFrancis CordovaChandra DassGilbert D’AlonzoParag DesaiMichael JacobsSteven KelsenA. James MamaryNathaniel MarchettiAditi SattiKartik ShenoyRobert M. SteinerMaria Elena Vega-SanchezMark DransfieldWilliam BaileySurya BhattAnand IyerHrudaya NathGabriela OatesSushil SonavaneJ. Michael WellsJoe RamsdellTerri BeatyPaul FriedmanFerdouse BegumXavier SolerRobert BuschAndrew YenPeter J. CastaldiAlejandro P. ComellasMichael ChoBrad ThompsonDawn L. DeMeoCOPDGene InvestigatorsAdel R. BoueizJoanne BillingsMarilyn G. ForemanAbbie BegnaudEitan Halper-StrombergTadashi AllenNadia N. HanselFrank SciurbaJessica BonDivay ChandraCarl FuhrmanJoel WeissfeldAntonio AnzuetoSandra AdamsDiego Maselli-CaceresMario E. Ruiz
- Resource Type
- Journal article
- Publication Details
- Chest, Vol.156(4), pp.685-695
- DOI
- 10.1016/j.chest.2019.03.041
- PMID
- 31047955
- PMCID
- PMC6859248
- NLM abbreviation
- Chest
- ISSN
- 0012-3692
- eISSN
- 1931-3543
- Publisher
- Elsevier Inc
- Grant note
- COPD Foundation (https://doi.org/10.13039/100008184) U01 HL089897; U01 HL089856 / National Heart, Lung, and Blood Institute (https://doi.org/10.13039/100000050) GlaxoSmithKline (https://doi.org/10.13039/100004330) AstraZeneca (https://doi.org/10.13039/100004325) Boehringer Ingelheim Novartis (https://doi.org/10.13039/100004336)
- Language
- English
- Date published
- 10/2019
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Pulmonary, Critical Care, and Occupational Medicine; Psychiatry; ICTS; Internal Medicine
- Record Identifier
- 9984318821902771
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