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The Structure and Predictive Validity of the Internalizing Disorders
Journal article

The Structure and Predictive Validity of the Internalizing Disorders

Nicholas R Eaton, Robert F Krueger, Katherine M Keyes, Melanie Wall, Deborah S Hasin, Kristian E Markon, Andrew E Skodol and Bridget F Grant
Journal of abnormal psychology (1965), Vol.122(1), pp.86-92
02/2013
DOI: 10.1037/a0029598
PMCID: PMC3755742
PMID: 22905862
url
https://www.ncbi.nlm.nih.gov/pmc/articles/3755742View
Open Access

Abstract

Multivariate comorbidity research indicates mood and anxiety (internalizing) disorders share one or more common liabilities, but categorical, dimensional, and hybrid accounts of these liabilities have not been directly compared. We modeled seven internalizing disorders in a nationally representative sample of 43,093 individuals via confirmatory factor, latent class, exploratory factor mixture, and exploratory structural equation modeling analyses. A two-dimensional (distress-fear) liability structure fit best and replicated across gender, assessment waves, and lifetime/12-month diagnoses. These liabilities, not disorder-specific variation, predicted future internalizing pathology, suicide attempts, angina, and ulcer.
Psychopathology anxiety classes depression dimensions internalizing

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