Journal article
The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): Rationale and Methods
American journal of epidemiology, Vol.193(12), pp.1650-1661
12/02/2024
DOI: 10.1093/aje/kwae116
PMCID: PMC11637526
PMID: 38881045
Abstract
Despite increasing prevalence of hypertension in youth and high adult cardiovascular mortality rates, the long-term consequences of youth-onset hypertension remain unknown. This is due to limitations of prior research such as small sample sizes, reliance on manual record review, and limited analytic methods that did not address major biases. The Study of the Epidemiology of Pediatric Hypertension (SUPERHERO) is a multisite retrospective Registry of youth evaluated by subspecialists for hypertension disorders. Sites obtain harmonized electronic health record data using standardized biomedical informatics scripts validated with randomized manual record review. Inclusion criteria are index visit for International Classification of Diseases Diagnostic Codes, 10th Revision (ICD-10 code)-defined hypertension disorder ≥January 1, 2015 and age <19 years. We exclude patients with ICD-10 code-defined pregnancy, kidney failure on dialysis, or kidney transplantation. Data include demographics, anthropomorphics, U.S. Census Bureau tract, histories, blood pressure, ICD-10 codes, medications, laboratory and imaging results, and ambulatory blood pressure. SUPERHERO leverages expertise in epidemiology, statistics, clinical care, and biomedical informatics to create the largest and most diverse registry of youth with newly diagnosed hypertension disorders. SUPERHERO's goals are to (i) reduce CVD burden across the life course and (ii) establish gold-standard biomedical informatics methods for youth with hypertension disorders.
Details
- Title: Subtitle
- The Study of the Epidemiology of Pediatric Hypertension Registry (SUPERHERO): Rationale and Methods
- Creators
- Andrew M SouthVictoria C GiammatteiKiri W BagleyChristine Y BakhoumWilliam H BeasleyMorgan B BilyShupti BiswasAaron M BridgesRushelle L ByfieldJessica Fallon CampbellRahul ChanchlaniAshton ChenLucy D'Agostino McGowanStephen M DownsGina M FergesonJason H GreenbergTaylor A Hill-HorowitzElizabeth T JensenMahmoud KallashMargret KamelStefan G KiesslingDavid M KlineJohn R LaisureGang LiuJackson LondereeCaroline B LucasSai Sudha MannemuddhuKuo-Rei MaoJason M MisuracMargaret O MurphyJames T NugentElizabeth A OnughaAshna PudupakkamKathy M RedmondSandeep RiarChristine B SethnaSahar SiddiquiAshley L ThumannStephen R UssCarol L VincentIrina V VivianoMichael J WalshBlanche D WhiteRobert P WoronieckiMichael WuIkuyo YamaguchiEmily YunDonald J Weaver
- Resource Type
- Journal article
- Publication Details
- American journal of epidemiology, Vol.193(12), pp.1650-1661
- DOI
- 10.1093/aje/kwae116
- PMID
- 38881045
- PMCID
- PMC11637526
- NLM abbreviation
- Am J Epidemiol
- ISSN
- 0002-9262
- eISSN
- 1476-6256
- Publisher
- OXFORD UNIV PRESS INC
- Grant note
We thank the biomedical informatics and manual record review teams at each site, the Center for Artificial Intelligence Research and Department of Pediatrics at Wake Forest University School of Medicine, and the Department of Pediatrics at Atrium Health Levine Children's Hospital for their support. We thank Dr. Donald L. Batisky for his invaluable encouragement; Dr. Batisky reports no relevant conflicts of interest. We have presented preliminary data from portions of the study in abstract form 64 times at national and international conferences from 2022 to May 2024, including the American Heart Association Hypertension Scientific Sessions, American Society of Nephrology Kidney Week, Pediatric Academic Societies Annual Meeting, Canadian Hypertension Congress, and Annual Congress of the International Pediatric Nephrology Association.
- Language
- English
- Electronic publication date
- 06/17/2024
- Date published
- 12/02/2024
- Academic Unit
- Nephrology, Dialysis and Transplantation; Stead Family Department of Pediatrics
- Record Identifier
- 9984642859602771
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