Journal article
The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage
Neurocritical care, Vol.21(3), pp.551-559
12/2014
DOI: 10.1007/s12028-014-9990-y
PMID: 24865271
Abstract
Researchers and other stakeholders continue to express concern about the failure of randomized clinical trials (RCT) in subarachnoid hemorrhage (SAH) to show efficacy of new treatments. Pooled data may be particularly useful to generate hypotheses about causes of poor outcomes and reasons for failure of RCT in SAH, and strategies to improve them. Investigators conducting SAH research collaborated to share data with the intent to develop a large repository of pooled individual patient data for exploratory analysis and testing of new hypotheses relevant to improved trial design and analysis in SAH. This repository currently contains information on 11,443 SAH patients from 14 clinical databases, of which 9 are datasets of recent RCTs and 5 are datasets of prospective observational studies and hospital registries. Most patients were managed in the last 15 years. Data validation and quality checks have been conducted and are satisfactory. Data is available on demographic, clinical, neuroimaging, and laboratory results and various outcome measures. We have compiled the largest known dataset of patients with SAH. The SAHIT repository may be an important resource for advancing clinical research in SAH and will benefit from contributions of additional datasets.
Details
- Title: Subtitle
- The Subarachnoid Hemorrhage International Trialists (SAHIT) Repository: advancing clinical research in subarachnoid hemorrhage
- Creators
- Blessing N R Jaja - Division of Neurosurgery, Department of Surgery, St. Michael's Hospital, Labatt Family Centre of Excellence in Brain Injury and Trauma Research, Keenan Research Centre of the Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, 30 Bond Street, Toronto, ON, M5B 1W8, CanadaDaniel AttallaR Loch MacdonaldTom A SchweizerMichael D CusimanoNima EtminanDaniel HanggiDavid HasanS Claiborne Johnston - University of California, San FranciscoPeter Le RouxBenjamin LoAda Louffat-OlivaresStephan MayerAndrew MolyneuxAdam NobleAudrey QuinnThomas SchenkJulian SpearsJeffrey SinghMichael ToddJames TornerMing TsengMervyn D I VergouwenWilliam van den Bergh - University Medical Center GroningenGeorge K C Wong
- Resource Type
- Journal article
- Publication Details
- Neurocritical care, Vol.21(3), pp.551-559
- DOI
- 10.1007/s12028-014-9990-y
- PMID
- 24865271
- NLM abbreviation
- Neurocrit Care
- ISSN
- 1541-6933
- eISSN
- 1556-0961
- Publisher
- United States
- Grant note
- Canadian Institutes of Health Research
- Language
- English
- Date published
- 12/2014
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Epidemiology; Surgery; Anesthesia; Injury Prevention Research Center; Neurosurgery; Otolaryngology
- Record Identifier
- 9983996192402771
Metrics
39 Record Views