Journal article
The Syk family of protein tyrosine kinases in T-cell activation and development
Immunological reviews, Vol.165(1), pp.167-180
10/1998
DOI: 10.1111/j.1600-065X.1998.tb01238.x
PMID: 9850860
Abstract
The processes of T-cell development and activation employ similar immature and mature receptors as well as similar signal transduction pathways to achieve different outcomes. Many signaling molecules are shared between the receptor signaling pathways, including two families of cytoplasmic protein tyrosine kinases, the Src family and the Syk family. The two Syk family members expressed in T cells, Syk and ZAP-70, are structurally similar but are expressed at different times during thymic development and during T-cell activation. These two kinases, although they share many physical features, differ in terms of biochemical activity and regulation. We discuss the overlapping and distinct characteristics of Syk and ZAP-70 in T-cell signaling and the potential biological importance of their differences.
Details
- Title: Subtitle
- The Syk family of protein tyrosine kinases in T-cell activation and development
- Creators
- David H Chu - Department of Microbiology and Immunology, University of California, San Francisco, California, USACraig T Morita - lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachtisetts, USAArthur Weiss - Department of Microbiology and Immunology, University of California, San Francisco, California, USA
- Resource Type
- Journal article
- Publication Details
- Immunological reviews, Vol.165(1), pp.167-180
- Publisher
- Blackwell Publishing Ltd
- DOI
- 10.1111/j.1600-065X.1998.tb01238.x
- PMID
- 9850860
- ISSN
- 0105-2896
- eISSN
- 1600-065X
- Number of pages
- 14
- Language
- English
- Date published
- 10/1998
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094770902771
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