Journal article
The Sympathetic Nervous System in Hypertension
Clinical and experimental hypertension (1993), Vol.A6(1-2), pp.43-60
1984
DOI: 10.3109/10641968409062550
PMID: 6697560
Abstract
Sympathetic drive can contribute not only to the acute adjustment to circulatory stresses but also to sustained elevation in vascular resistance and arterial pressure. In hypertensive animals and humans excessive sympathetic activity coupled with a possible genetic factor may result in defects in electrogenic ion transport of vascular muscle or in excessive vascular hypertrophy. Increased sympathetic activity and release of the neurotransmitter may occur as a result of defects of the efferent, afferent or central components of the sympathetic system. Several studies in various animal models and in humans are described to support the notion that the mosaic concept in hypertension may be embodied in a dual theory that includes a vascular muscle defect coupled with excessive sympathetic drive both of which may be of genetic or acquired origin. Almost regardless of the cause of hypertension, interruption of sympathetic efferent activity lowers arterial pressure.
Details
- Title: Subtitle
- The Sympathetic Nervous System in Hypertension
- Creators
- Francois M Abboud - Departments of Medicine and Physiology, The University of Iowa College of Medicine, Iowa City, Iowa, 52242
- Resource Type
- Journal article
- Publication Details
- Clinical and experimental hypertension (1993), Vol.A6(1-2), pp.43-60
- Publisher
- Informa UK Ltd
- DOI
- 10.3109/10641968409062550
- PMID
- 6697560
- ISSN
- 1064-1963
- eISSN
- 1525-6006
- Language
- English
- Date published
- 1984
- Academic Unit
- Molecular Physiology and Biophysics; Cardiovascular Medicine; Fraternal Order of Eagles Diabetes Research Center; Internal Medicine
- Record Identifier
- 9984025559002771
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