Journal article
The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease
Biomarkers in Medicine, Vol.11(4), pp.359-368
04/01/2017
DOI: 10.2217/bmm-2016-0366
PMID: 28353371
Abstract
The search for a biomarker for Parkinson's disease (PD) has led to a surge in literature describing peripheral α-synuclein (aSyn) in both biofluids and biopsy/autopsy tissues. Despite encouraging results, attempts to capitalize on this promise have fallen woefully short. The Systemic Synuclein Sampling Study (S4) is uniquely designed to identify a reproducible diagnostic and progression biomarker for PD. S4 will evaluate aSyn in multiple tissues and biofluids within the same subject and across the disease spectrum to identify the optimal biomarker source and provide vital information on the evolution of peripheral aSyn throughout the disease. Additionally, S4 will correlate the systemic aSyn profile with an objective measure of nigrostriatal dopaminergic function furthering our understanding of the pathophysiological progression of PD.
Details
- Title: Subtitle
- The Systemic Synuclein Sampling Study: toward a biomarker for Parkinson's disease
- Creators
- Naomi P VisanjiBrit MollenhauerThomas G BeachCharles H AdlerChristopher S CoffeyCatherine M KopilKuldip D DaveTatiana ForoudLana ChahineDanna Jenningsthe Systemic Synuclein Sampling Study (S4)
- Resource Type
- Journal article
- Publication Details
- Biomarkers in Medicine, Vol.11(4), pp.359-368
- DOI
- 10.2217/bmm-2016-0366
- PMID
- 28353371
- NLM abbreviation
- Biomark Med
- ISSN
- 1752-0363
- eISSN
- 1752-0371
- Publisher
- Future Medicine Ltd
- Language
- English
- Date published
- 04/01/2017
- Academic Unit
- Biostatistics
- Record Identifier
- 9983997999402771
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