Journal article
The TREM receptor family and signal integration
Nature immunology, Vol.7(12), pp.1266-1273
12/2006
DOI: 10.1038/ni1411
PMID: 17110943
Abstract
TREM proteins are a family of cell surface receptors that participate in diverse cell processes, including inflammation, bone homeostasis, neurological development and coagulation. TREM-1, the first to be identified, acts to amplify inflammation. Other TREM proteins regulate the differentiation and function of macrophages, microglia, dendritic cells, osteoclasts and platelets. Here we discuss the state of the field, putative ligands of TREM proteins and the challenges that remain in understanding TREM biology.
Details
- Title: Subtitle
- The TREM receptor family and signal integration
- Creators
- Isaiah R Turnbull - Washington University School of Medicine, Department of Pathology and ImmunologyJulia Klesney-Tait - Washington University School of Medicine, Department of Pathology and ImmunologyMarco Colonna - Washington University School of Medicine, Department of Pathology and Immunology
- Resource Type
- Journal article
- Publication Details
- Nature immunology, Vol.7(12), pp.1266-1273
- DOI
- 10.1038/ni1411
- PMID
- 17110943
- ISSN
- 1529-2908
- eISSN
- 1529-2916
- Language
- English
- Date published
- 12/2006
- Academic Unit
- Pulmonary, Critical Care, and Occupational Medicine; Internal Medicine
- Record Identifier
- 9984094490202771
Metrics
25 Record Views