Journal article
The Tolerability and Efficacy of 4 mA Transcranial Direct Current Stimulation on Leg Muscle Fatigability
Brain sciences, Vol.10(1), p.12
01/01/2020
DOI: 10.3390/brainsci10010012
PMCID: PMC7017217
PMID: 31878058
Abstract
Transcranial direct current stimulation (tDCS) modulates cortical excitability and affects a variety of outcomes. tDCS at intensities <= 2 mA is well-tolerated, but the tolerability and efficacy of tDCS at intensities >2 mA merits systematic investigation. The study objective was to determine the tolerability and effects of 4 mA tDCS on leg muscle fatigability. Thirty-one young, healthy adults underwent two randomly ordered tDCS conditions (sham, 4 mA) applied before and during an isokinetic fatigue test of the knee extensors and flexors. Subjects reported the severity of the sensations felt from tDCS. Primary outcomes were sensation tolerability and the fatigue index of the knee extensors and flexors. A repeated-measures ANOVA determined statistical significance (p < 0.05). Sensation severity at 4 mA tDCS was not substantially different than sham. However, two subjects reported a moderate-severe headache, which dissipated soon after the stimulation ended. The left knee flexors had significantly greater fatigability with 4 mA tDCS compared with sham (p = 0.018). tDCS at 4 mA was well-tolerated by young, healthy subjects and increased left knee flexor fatigability. Exploration of higher intensity tDCS (>2 mA) to determine the potential benefits of increasing intensity, especially in clinical populations with decreased brain activity/excitability, is warranted.
Details
- Title: Subtitle
- The Tolerability and Efficacy of 4 mA Transcranial Direct Current Stimulation on Leg Muscle Fatigability
- Creators
- Craig D. Workman - University of IowaJohn Kamholz - University of Iowa Hospitals and ClinicsThorsten Rudroff - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Brain sciences, Vol.10(1), p.12
- DOI
- 10.3390/brainsci10010012
- PMID
- 31878058
- PMCID
- PMC7017217
- NLM abbreviation
- Brain Sci
- ISSN
- 2076-3425
- eISSN
- 2076-3425
- Publisher
- Mdpi
- Number of pages
- 13
- Language
- English
- Date published
- 01/01/2020
- Academic Unit
- Neurology; Psychiatry; Health, Sport, and Human Physiology
- Record Identifier
- 9984259652602771
Metrics
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