Journal article
The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease
Journal of immunology research, Vol.2016, pp.8249015-9
2016
DOI: 10.1155/2016/8249015
PMCID: PMC4779544
PMID: 26998496
Abstract
Peripheral artery disease (PAD) can result in limb loss within six months of diagnosis in a subset of patients who cannot undergo endovascular or surgical revascularization yet continues to maintain a marginal position in cardiovascular research. While a body of literature continues to grow describing the role of danger signaling and innate immunity in cardiac biology, the role of these pathways in the ischemic myopathy associated with PAD has not been extensively studied. The following report will review the current literature on the role of Toll-like receptor (TLR) signaling in cardiovascular biology as well as in nonischemic myopathy. While attenuation of TLR signaling has not been shown to be clinically useful in the treatment of infectious inflammation, it may show promise in the management of severe arterial insufficiency.
Details
- Title: Subtitle
- The Toll of Vascular Insufficiency: Implications for the Management of Peripheral Arterial Disease
- Creators
- Jun Xu - Division of Vascular Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite A1011, Pittsburgh, PA 15213, USAUlka Sachdev - Division of Vascular Surgery, University of Pittsburgh Medical Center, 200 Lothrop Street, Suite A1011, Pittsburgh, PA 15213, USA
- Resource Type
- Journal article
- Publication Details
- Journal of immunology research, Vol.2016, pp.8249015-9
- DOI
- 10.1155/2016/8249015
- PMID
- 26998496
- PMCID
- PMC4779544
- NLM abbreviation
- J Immunol Res
- ISSN
- 2314-8861
- eISSN
- 2314-7156
- Publisher
- Egypt
- Language
- English
- Date published
- 2016
- Academic Unit
- Surgery
- Record Identifier
- 9984051900102771
Metrics
23 Record Views