Journal article
The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods
European child & adolescent psychiatry, Vol.24(2), pp.141-151
02/2015
DOI: 10.1007/s00787-014-0543-x
PMCID: PMC4209328
PMID: 24771252
Abstract
Tourette syndrome (TS) is a neuropsychiatric disorder characterized by recurrent motor and vocal tics, often accompanied by obsessive–compulsive disorder and/or attention-deficit/hyperactivity disorder. While the evidence for a genetic contribution is strong, its exact nature has yet to be clarified fully. There is now mounting evidence that the genetic risks for TS include both common and rare variants and may involve complex multigenic inheritance or, in rare cases, a single major gene. Based on recent progress in many other common disorders with apparently similar genetic architectures, it is clear that large patient cohorts and open-access repositories will be essential to further advance the field. To that end, the large multicenter Tourette International Collaborative Genetics (TIC Genetics) study was established. The goal of the TIC Genetics study is to undertake a comprehensive gene discovery effort, focusing both on familial genetic variants with large effects within multiply affected pedigrees and on de novo mutations ascertained through the analysis of apparently simplex parent–child trios with non-familial tics. The clinical data and biomaterials (DNA, transformed cell lines, RNA) are part of a sharing repository located within the National Institute for Mental Health Center for Collaborative Genomics Research on Mental Disorders, USA, and will be made available to the broad scientific community. This resource will ultimately facilitate better understanding of the pathophysiology of TS and related disorders and the development of novel therapies. Here, we describe the objectives and methods of the TIC Genetics study as a reference for future studies from our group and to facilitate collaboration between genetics consortia in the field of TS.
Details
- Title: Subtitle
- The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods
- Creators
- Andrea Dietrich - Department of Psychiatry, University Medical Center Groningen University of Groningen Groningen The NetherlandsThomas Fernandez - Yale Child Study Center and Department of Psychiatry Yale University School of Medicine New Haven CT USARobert King - Yale Child Study Center and Department of Psychiatry Yale University School of Medicine New Haven CT USAMatthew State - Department of Psychiatry University of California San Francisco USAJay Tischfield - Department of Genetics, The Human Genetics Institute of New Jersey Rutgers, the State University of New Jersey Life Science Building, 145 Bevier Road Piscataway NJ 08854-8082 USAPieter Hoekstra - Department of Psychiatry, University Medical Center Groningen University of Groningen Groningen The NetherlandsGary Heiman - Department of Genetics, The Human Genetics Institute of New Jersey Rutgers, the State University of New Jersey Life Science Building, 145 Bevier Road Piscataway NJ 08854-8082 USATIC Genetics Collaborative Group
- Contributors
- Samuel Kuperman (Contributor) - University of Iowa, Psychiatry
- Resource Type
- Journal article
- Publication Details
- European child & adolescent psychiatry, Vol.24(2), pp.141-151
- DOI
- 10.1007/s00787-014-0543-x
- PMID
- 24771252
- PMCID
- PMC4209328
- NLM abbreviation
- Eur Child Adolesc Psychiatry
- ISSN
- 1018-8827
- eISSN
- 1435-165X
- Publisher
- Springer Berlin Heidelberg; Berlin/Heidelberg
- Language
- English
- Date published
- 02/2015
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003964302771
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